# Kelch like ECH associated protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173646](https://www.wikidata.org/wiki/Q21173646)  
**Source**: https://4ort.xyz/entity/kelch-like-ech-associated-protein-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14145)
3. Q20641742
4. [DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14145&geneProductId=UniProtKB:Q14145)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14145&geneProductId=UniProtKB:Q14145)
6. [Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
7. [Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
8. [Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
9. [Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
10. [Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
11. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
12. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
13. [Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
14. [Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
15. [DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
16. [Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
17. [Defining the human deubiquitinating enzyme interaction landscape](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
18. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
19. [p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
20. [Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
21. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
22. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
23. [The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
24. [A mechanism for the suppression of homologous recombination in G1 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
25. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
26. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
27. [Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
30. [Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
31. [Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14145)
32. Ensembl Release 99