# Jun proto-oncogene, AP-1 transcription factor subunit

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5005943](https://www.wikidata.org/wiki/Q5005943)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Transcription_factor_Jun)  
**Source**: https://4ort.xyz/entity/jun-proto-oncogene-ap-1-transcription-factor-subunit


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P05412)
3. Q20641742
4. [ARAP1: a point of convergence for Arf and Rho signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
6. [Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412)
8. [Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412)
9. [cJun modulates Ggamma-globin gene expression via an upstream cAMP response element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
10. [Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
12. [miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05412&geneProductId=UniProtKB:P05412)
13. [A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
14. [The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
15. [Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
16. [Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
17. [Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
18. [TAF7 (TAFII55) plays a role in the transcription activation by c-Jun](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
19. [Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
20. [Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
21. [Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
22. [The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
23. [Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
24. [The C-terminal region of human NFATc2 binds cJun to synergistically activate interleukin-2 transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
25. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
26. [3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
27. [Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
28. [In situ proximity ligation detection of c-Jun/AP-1 dimers reveals increased levels of c-Jun/Fra1 complexes in aggressive breast cancer cell lines in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
29. [Thermodynamic analysis of Jun-Fos coiled coil peptide antagonists](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
30. [UNC-16, a JNK-Signaling Scaffold Protein, Regulates Vesicle Transport in C. elegans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
31. [The tyrosine kinase Syk regulates TPL2 activation signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
32. [Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
33. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
34. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
35. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
36. [A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
37. [The same pocket in menin binds both MLL and JUND but has opposite effects on transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
38. [Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
39. [Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
40. [c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
41. [Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
42. [The protein interaction landscape of the human CMGC kinase group](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
43. [Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
44. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
45. [A selective small-molecule inhibitor of c-Jun N-terminal kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
46. [Visualization of AP-1 NF-kappaB ternary complexes in living cells by using a BiFC-based FRET.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
47. [Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
48. [Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
49. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)
50. [Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05412)