# Jun proto-oncogene, AP-1 transcription factor subunit

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558631](https://www.wikidata.org/wiki/Q28558631)  
**Source**: https://4ort.xyz/entity/jun-proto-oncogene-ap-1-transcription-factor-subunit-q28558631


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P17325)
3. Q20641742
4. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
6. [dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
7. [Basic fibroblast growth factor stimulates collagenase-3 promoter activity in osteoblasts through an activator protein-1-binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
8. [Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
9. [c-Jun is regulated by combination of enhanced expression and phosphorylation in acute-overloaded rat heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
10. [JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
11. [Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
12. [A dominant negative Egr inhibitor blocks nerve growth factor-induced neurite outgrowth by suppressing c-Jun activation: role of an Egr/c-Jun complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
13. [Modulation of cellular AP‐1 DNA binding activity by heat shock proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
14. [Alterations in the DNA binding activity of transcriptional factors activator protein-1, Sp1, and hepatocyte nuclear factor-1 in rat jejunum during starvation and refeeding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
15. [The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
16. [The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
17. [Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
18. [Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
19. [Impaired activation of AP-1 and altered expression of constituent proteins in rat adrenal during ageing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
20. [Sequence-specific impairment of learning by c-jun antisense oligonucleotides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
21. [Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
22. [Identification of c-Jun as a critical mediator for the intracrine 24 kDa FGF-2 isoform-induced cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
23. [Inactivation of AP1 proteins by a nuclear serine protease precedes the onset of radiation-induced fibrosing alveolitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
24. [Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
25. [4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
26. [The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
27. [Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
28. [H(2)O(2)-induced egr-1, fra-1, and c-jun gene expression is mediated by tyrosine kinase in aortic smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
29. [Increased expression and activation of c-Jun contributes to human amylin-induced apoptosis in pancreatic islet beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
30. [POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
31. [Activity deprivation-dependent induction of the proapoptotic BH3-only protein Bim is independent of JNK/c-Jun activation during apoptosis in cerebellar granule neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
32. [Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
33. [Differentiation of WEHI-3B D+ myelomonocytic leukemia cells induced by ectopic expression of the protooncogene c-jun](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
34. [The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
35. [c-Jun decreases voltage-gated K(+) channel activity in pulmonary artery smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
36. [miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17325)
37. ensembl Release 106