# Janus kinase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3162114](https://www.wikidata.org/wiki/Q3162114)  
**Source**: https://4ort.xyz/entity/janus-kinase-2


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1078178)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3622821)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1231124)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3545215)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2107823)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3137308)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1944698)
10. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O60674)
11. Q20641742
12. [Interaction of Human Suppressor of Cytokine Signaling (SOCS)-2 with the Insulin-like Growth Factor-I Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
14. [CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
16. [Heme controls the regulation of protein tyrosine kinases Jak2 and Src](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
17. [JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674)
18. [JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
19. [Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
20. [hTid-1, a Human DnaJ Protein, Modulates the Interferon Signaling Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
21. [RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
22. [Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
23. [TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
24. [The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
25. [PTP1B regulates leptin signal transduction in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
26. [Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
27. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
28. [Mpl traffics to the cell surface through conventional and unconventional routes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
29. [JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
30. [CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
31. [Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
32. [The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
33. [The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
34. [Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
35. [Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
36. [Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
37. [Tyrosines 868, 966, and 972 in the Kinase Domain of JAK2 Are Autophosphorylated and Required for Maximal JAK2 Kinase Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
38. [Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
39. [Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
40. [The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
41. [Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
42. [The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
43. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674)
44. [IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
45. [Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
46. [The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
47. [Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
48. [IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60674&geneProductId=UniProtKB:O60674)
49. [JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60674)
50. Ensembl Release 99