# Janus kinase 2

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28563318](https://www.wikidata.org/wiki/Q28563318)  
**Source**: https://4ort.xyz/entity/janus-kinase-2-q28563318


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q62689)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
5. [AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
6. [Growth hormone receptor interaction with Jak proteins differs between tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
7. [The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
9. [SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
10. [Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
11. [Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
12. [Role of Angiotensin II in Activation of the JAK/STAT Pathway Induced by Acute Pressure Overload in the Rat Heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
13. [Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
14. [Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
15. [Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
16. [Constitutive nuclear localization of Janus kinases 1 and 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
17. [Kinase activity and subcellular distribution of a chimeric green fluorescent protein-tagged Janus kinase 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
18. [The Jak/STAT pathway is involved in synaptic plasticity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
19. [Janus kinase-2 signaling mediates apoptosis in rat cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
20. [An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
21. [Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
22. [Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
23. [Sequential activation of JAKs, STATs and xanthine dehydrogenase/oxidase by hypoxia in lung microvascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
24. [Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
25. [JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
26. [Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
27. [Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
28. [Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
29. [An essential role of the Jak-2/STAT-3/cytosolic phospholipase A(2) axis in platelet-derived growth factor BB-induced vascular smooth muscle cell motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
30. [Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
31. [JAK2/STAT3, not ERK1/2, mediates interleukin-6-induced activation of inducible nitric-oxide synthase and decrease in contractility of adult ventricular myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
32. [Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
33. [Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
34. [Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
35. [JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
36. [Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase‐2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
37. [JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
38. [Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
39. [Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
40. [Suppression of JAK2/STAT3 signaling reduces end-to-end arterial anastomosis induced cell proliferation in common carotid arteries of rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62689)
41. ensembl Release 106