# Janus kinase 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q14914518](https://www.wikidata.org/wiki/Q14914518)  
**Source**: https://4ort.xyz/entity/janus-kinase-2-q14914518


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q62120)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
5. [A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
7. [Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
8. [Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
9. [Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
10. [Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
11. [A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
12. [Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
13. [Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
14. [Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
15. [A role for the ITAM signaling module in specifying cytokine-receptor functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
16. [Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
17. [Differential biological activity of disease-associated JAK2 mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
18. [Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
19. [Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
20. [Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120)
22. [The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120)
23. [Tyrosines 868, 966, and 972 in the Kinase Domain of JAK2 Are Autophosphorylated and Required for Maximal JAK2 Kinase Activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120)
24. [Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120)
25. [Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120)
26. [Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120)
27. [The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
28. [Tyrosines 868, 966, and 972 in the Kinase Domain of JAK2 Are Autophosphorylated and Required for Maximal JAK2 Kinase Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
29. [Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
30. [Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
31. [Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
32. [Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
33. [Epo regulates erythroid proliferation and differentiation through distinct signaling pathways: implication for erythropoiesis and Friend virus-induced erythroleukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
34. [Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
35. [Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
36. [Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
37. [Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
38. [Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
39. [Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
40. [Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
41. [Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
42. [Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120)
43. [Jak2 is essential for signaling through a variety of cytokine receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62120&geneProductId=UniProtKB:Q62120)
44. [The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
45. [Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
46. [Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
47. [Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
48. [JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
49. [Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)
50. [Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62120)