# Janus kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6155967](https://www.wikidata.org/wiki/Q6155967)  
**Source**: https://4ort.xyz/entity/janus-kinase-1-q6155967


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3301607)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1078178)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3622821)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3137308)
7. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P23458)
8. Q20641742
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
10. [The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458)
12. [Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
13. [CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
14. [Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
15. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
16. [UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
17. [Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
18. [Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
19. [The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
20. [A protein tyrosine kinase in the interferon alpha/beta signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
21. [The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
22. [Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
23. [The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
25. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458)
26. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
27. [The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
28. [Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P23458)
29. [The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P23458&geneProductId=UniProtKB:P23458)
30. ensembl Release 96
31. UMLS 2023