# Jagged canonical Notch ligand 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3780451](https://www.wikidata.org/wiki/Q3780451)  
**Source**: https://4ort.xyz/entity/jagged-canonical-notch-ligand-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P78504)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
6. [A non-transmembrane form of Jagged-1 regulates the formation of matrix-dependent chord-like structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
7. [Identification and Cloning of the Human Homolog (JAG1) of the RatJagged1Gene from the Alagille Syndrome Critical Region at 20p12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
8. [Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
9. [The CD46-Jagged1 interaction is critical for human TH1 immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
10. [A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
11. [The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
12. [Flexibility of the PDZ-binding motif in the micelle-bound form of Jagged-1 cytoplasmic tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
13. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
14. [Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
15. [Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78504&geneProductId=UniProtKB:P78504)
17. [Identification and Cloning of the Human Homolog (JAG1) of the RatJagged1Gene from the Alagille Syndrome Critical Region at 20p12](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78504&geneProductId=UniProtKB:P78504)
18. [Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P78504&geneProductId=UniProtKB:P78504)
19. [Mutations in the human Jagged1 gene are responsible for Alagille syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
20. [Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
21. [Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
22. [Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
23. [Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
24. [An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
25. [Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
26. [Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
27. [NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P78504)
28. Ensembl Release 99
29. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
30. UMLS 2023