# Itchy E3 ubiquitin protein ligase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109507](https://www.wikidata.org/wiki/Q21109507)  
**Source**: https://4ort.xyz/entity/itchy-e3-ubiquitin-protein-ligase-q21109507


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q96J02)
3. Q20641742
4. [The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
5. [Atrophin-1, the DRPLA Gene Product, Interacts with Two Families of WW Domain-Containing Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
6. [The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
7. [The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein–coupled receptor CXCR4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
8. [The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
9. [Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
10. [The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
11. [Interactions of ErbB4 and Kap1 Connect the Growth Factor and DNA Damage Response Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
12. [Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
13. [The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
14. [The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
15. [Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
16. [The E3 ubiquitin ligase Itch controls the protein stability of p63](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
17. [Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
18. [Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
19. [The ubiquitin-protein ligase Itch regulates p73 stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
20. [The E3 ubiquitin ligase Itch and Yap1 have antagonistic roles in the regulation of ASPP2 protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
21. [Identification of the WW domain-interaction sites in the unstructured N-terminal domain of EBV LMP 2A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
22. [CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
23. [Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
24. [PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
27. [The ubiquitin-protein ligase Itch regulates p73 stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
28. [Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
29. [Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
31. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
32. [The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
33. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
34. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
35. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
36. [Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
37. [AIP4/Itch regulates Notch receptor degradation in the absence of ligand](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
38. [ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
39. [Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
40. [The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
41. [Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
42. [The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
43. [PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
44. [The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein–coupled receptor CXCR4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
45. [Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
46. [The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96J02&geneProductId=UniProtKB:Q96J02)
47. [Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
48. [AIP4/Itch regulates Notch receptor degradation in the absence of ligand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
49. [ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)
50. [Itch regulates p45/NF-E2 in vivo by Lys63-linked ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96J02)