# ITCH

> protein-coding gene in the species Homo sapiens

**Wikidata**: [Q18047255](https://www.wikidata.org/wiki/Q18047255)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/ITCH)  
**Source**: https://4ort.xyz/entity/itch-q18047255


## References

1. ensembl Release 105
2. UniProt
3. NCBI homo sapiens annotation release 107
4. Q20641742
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8C863)
6. Online Mendelian Inheritance in Man
7. [Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
8. [The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
9. [The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
10. [The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
11. [The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
13. [The ubiquitin-protein ligase Itch regulates p73 stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
14. [The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
16. [Large-scale identification of mammalian proteins localized to nuclear sub-compartments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C863&geneProductId=UniProtKB:Q8C863)
18. [Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C863&geneProductId=UniProtKB:Q8C863)
19. [Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
20. [PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C863)
21. [The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C863&geneProductId=UniProtKB:Q8C863)
22. [The ubiquitin-protein ligase Itch regulates p73 stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C863&geneProductId=UniProtKB:Q8C863)
23. [The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C863&geneProductId=UniProtKB:Q8C863)
24. HomoloGene build68
25. [Orthologous MAtrix](https://omabrowser.org/oma/vps/Q96J02/)
26. ensembl Release 106
27. [Open Targets Platform](https://platform.opentargets.org/evidence/ENSG00000078747/MONDO_0013245)
28. [Identifiers.org](http://www.ebi.ac.uk/miriam/main/collections/MIR:00000069)
29. UMLS 2023
30. [Bgee](https://www.bgee.org/gene/ENSG00000078747)