# ISL1 transcription factor, LIM/homeodomain

> mammalian protein found in Mus musculus

**Wikidata**: [Q21986053](https://www.wikidata.org/wiki/Q21986053)  
**Source**: https://4ort.xyz/entity/isl1-transcription-factor-lim-homeodomain


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P61372)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
5. [A regulatory pathway involving Notch1/β-catenin/Isl1 determines cardiac progenitor cell fate.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
7. [The LIM/Homeodomain Protein Islet1 Recruits Janus Tyrosine Kinases and Signal Transducer and Activator of Transcription 3 and Stimulates Their Activities](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
8. [Brn3a and Islet1 Act Epistatically to Regulate the Gene Expression Program of Sensory Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
9. [ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
10. [Isl1 and Pou4f2 Form a Complex to Regulate Target Genes in Developing Retinal Ganglion Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
11. [A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
12. [RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
13. [CIP, a Cardiac Isl1-Interacting Protein, Represses Cardiomyocyte Hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
14. [The LIM/Homeodomain Protein Islet1 Recruits Janus Tyrosine Kinases and Signal Transducer and Activator of Transcription 3 and Stimulates Their Activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
15. [Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
16. [Implementing the LIM code: the structural basis for cell type‐specific assembly of LIM‐homeodomain complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
18. [Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
19. [Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
20. [Conversion of biliary system to pancreatic tissue in Hes1-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
21. [ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
22. [Nf2–Yap signaling controls the expansion of DRG progenitors and glia during DRG development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
23. [Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
24. [Role of Islet1 in the patterning of murine dentition](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
25. [Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
26. [Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
27. [Rnf165/Ark2C Enhances BMP-Smad Signaling to Mediate Motor Axon Extension](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
28. [Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
29. [Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
30. [Nf2–Yap signaling controls the expansion of DRG progenitors and glia during DRG development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
31. [Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
32. [Conversion of biliary system to pancreatic tissue in Hes1-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
33. [Role of Islet1 in the patterning of murine dentition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
34. [Rnf165/Ark2C Enhances BMP-Smad Signaling to Mediate Motor Axon Extension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
35. [Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
36. [A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
37. [Islet-1 gene delivery improves myocardial performance after experimental infarction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
38. [Formation of Rathke's pouch requires dual induction from the diencephalon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
39. [A Postmitotic Role for Isl-Class LIM Homeodomain Proteins in the Assignment of Visceral Spinal Motor Neuron Identity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
40. [A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
41. [Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
42. [β-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
43. [Islet-1 May Function as an Assistant Factor for Histone Acetylation and Regulation of Cardiac Development-Related Transcription Factor Mef2c Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
44. [Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
45. [Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
46. [Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron– Dependent Step in Interneuron Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
47. [The LIM-Homeobox GeneIslet-1Is Required for the Development of Restricted Forebrain Cholinergic Neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
48. [Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61372)
49. [Isl1 and Pou4f2 Form a Complex to Regulate Target Genes in Developing Retinal Ganglion Cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)
50. [A regulatory pathway involving Notch1/β-catenin/Isl1 determines cardiac progenitor cell fate.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61372&geneProductId=UniProtKB:P61372)