Interleukin 6 signal transducer
type: Thing
alternate name: Interleukin-6 signal transducer
alternate name: gp130
alternate name: gp130, oncostatin M receptor
alternate name: IL-6R subunit beta
alternate name: interleukin receptor beta chain
alternate name: interleukin-6 receptor subunit beta
alternate name: membrane glycoprotein gp130
alternate name: gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
alternate name: membrane glycoprotein 130
alternate name: IL-6 receptor subunit beta
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P40189
additional property: PropertyValue
  property ID: P361
  value: Fibronectin type III superfamily
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin-like fold
additional property: PropertyValue
  property ID: P361
  value: Fibronectin type III, protein family
additional property: PropertyValue
  property ID: P486
  value: D050822
additional property: PropertyValue
  property ID: P527
  value: Immunoglobulin C2-set-like, ligand-binding
additional property: PropertyValue
  property ID: P527
  value: Type I cytokine receptor, cytokine-binding domain
additional property: PropertyValue
  property ID: P527
  value: fibronectin type III
additional property: PropertyValue
  property ID: P637
  value: NP_001177910
additional property: PropertyValue
  property ID: P637
  value: NP_002175
additional property: PropertyValue
  property ID: P637
  value: NP_786943
additional property: PropertyValue
  property ID: P638
  value: 1BJ8
additional property: PropertyValue
  property ID: P638
  value: 1BQU
additional property: PropertyValue
  property ID: P638
  value: 1I1R
additional property: PropertyValue
  property ID: P646
  value: /m/0271f_0
additional property: PropertyValue
  property ID: P672
  value: D12.776.543.750.705.852.420.400.500
additional property: PropertyValue
  property ID: P672
  value: D12.776.543.750.705.852.420.560.249
additional property: PropertyValue
  property ID: P672
  value: D12.776.543.750.705.852.555.600.500
additional property: PropertyValue
  property ID: P680
  value: interleukin-11 binding
additional property: PropertyValue
  property ID: P680
  value: leukemia inhibitory factor receptor activity
additional property: PropertyValue
  property ID: P680
  value: ciliary neurotrophic factor receptor binding
additional property: PropertyValue
  property ID: P681
  value: extracellular exosome
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P682
  value: regulation of Notch signaling pathway
additional property: PropertyValue
  property ID: P682
  value: positive regulation of cardiac muscle hypertrophy
additional property: PropertyValue
  property ID: P682
  value: negative regulation of apoptotic process
additional property: PropertyValue
  property ID: P702
  value: IL6ST
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
confidence:
  popularity graph score:
    score: 0.01
    score pct: 1
    tier: established
    components:
      sitelinks: 6
      sitelinks norm: 0.014
      unique citations: 39
      unique citations norm: 0.015
      monthly pageviews: 65
      monthly pageviews norm: 0.0
  sitelinks: 6
  unique citations: 39
  monthly pageviews: 65
  yearly pageviews: 126
  pageview trend:
    m: 2026-08
    v: 65
  pageview trend:
    m: 2026-07
    v: 12
  pageview trend:
    m: 2026-06
    v: 27
  pageview trend:
    m: 2026-05
    v: 7
  pageview trend:
    m: 2026-04
    v: 15
  popularity:
    sitelinks: 6
    max: 423
    pct: 1.4
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P40189
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797245
    source count: 1
    confidence: 0.2
    value label: Fibronectin type III superfamily
  P361:
    value: Q24787648
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like fold
  P361:
    value: Q83137093
    source count: 1
    confidence: 0.2
    value label: Fibronectin type III, protein family
  P361:
    value: Q83141104
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin C2-set-like, ligand-binding domain, protein family
  P361:
    value: Q83136434
    source count: 1
    confidence: 0.2
    value label: Type I cytokine receptor, cytokine-binding domain, protein family
  P486:
    value: D050822
    source count: 0
    confidence: 0.0
  P527:
    value: Q24773534
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin C2-set-like, ligand-binding
  P527:
    value: Q24727145
    source count: 1
    confidence: 0.2
    value label: Type I cytokine receptor, cytokine-binding domain
  P527:
    value: Q24740327
    source count: 1
    confidence: 0.2
    value label: fibronectin type III
  P527:
    value: Q24771476
    source count: 1
    confidence: 0.2
    value label: Long hematopoietin receptor, Gp130 family 2, conserved site
  P637:
    value: NP_001177910
    source count: 1
    confidence: 0.2

value: NP_002175
source count: 1
confidence: 0.2

value: NP_786943
source count: 1
confidence: 0.2

value: NP_001351204
source count: 1
confidence: 0.2

value: NP_001351205
source count: 1
confidence: 0.2

value: 1BJ8
source count: 1
confidence: 0.2

value: 1BQU
source count: 1
confidence: 0.2

value: 1I1R
source count: 1
confidence: 0.2

value: 1P9M
source count: 1
confidence: 0.2

value: 1PVH
source count: 1
confidence: 0.2

value: /m/0271f_0
source count: 0
confidence: 0.0

value: D12.776.543.750.705.852.420.400.500
source count: 0
confidence: 0.0

value: D12.776.543.750.705.852.420.560.249
source count: 0
confidence: 0.0

value: D12.776.543.750.705.852.555.600.500
source count: 0
confidence: 0.0

value: D12.776.543.750.705.852.583.500
source count: 0
confidence: 0.0

value: D12.776.543.750.750.400.550.250.500
source count: 0
confidence: 0.0

value: Q14907590
source count: 1
confidence: 0.2
value label: interleukin-11 binding

value: Q14907588
source count: 2
confidence: 0.4
value label: leukemia inhibitory factor receptor activity

value: Q14906188
source count: 1
confidence: 0.2
value label: ciliary neurotrophic factor receptor binding

value: Q14907592
source count: 1
confidence: 0.2
value label: interleukin-27 receptor activity

value: Q14907585
source count: 1
confidence: 0.2
value label: ciliary neurotrophic factor receptor activity

value: Q903634
source count: 2
confidence: 0.4
value label: extracellular exosome

value: Q14645596
source count: 2
confidence: 0.4
value label: extracellular region

value: Q14327652
source count: 1
confidence: 0.2
value label: integral component of membrane

value: Q14864866
source count: 1
confidence: 0.2
value label: cell body

value: Q14907584
source count: 1
confidence: 0.2
value label: ciliary neurotrophic factor receptor complex

value: Q14907593
source count: 1
confidence: 0.2
value label: regulation of Notch signaling pathway

value: Q14859611
source count: 1
confidence: 0.2
value label: positive regulation of cardiac muscle hypertrophy

value: Q14599533
source count: 1
confidence: 0.2
value label: negative regulation of apoptotic process

value: Q14907595
source count: 1
confidence: 0.2
value label: negative regulation of interleukin-6-mediated signaling pathway

value: Q21418786
source count: 1
confidence: 0.2
value label: interleukin-11-mediated signaling pathway

value: Q14907597
source count: 1
confidence: 0.2
value label: IL6ST

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000338799
source count: 1
confidence: 0.2

value: ENSP00000370687
source count: 1
confidence: 0.2

value: ENSP00000370694
source count: 1
confidence: 0.2

value: ENSP00000370698
source count: 1
confidence: 0.2

value: ENSP00000435399
source count: 1
confidence: 0.2

value: C0082758
source count: 1
confidence: 0.2

value: 126037660
source count: 0
confidence: 0.0

value: 51128
source count: 0
confidence: 0.0

value: C126037660
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation
stated in qid: Q24313382
retrieved: 2017-10-17

source: Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF
stated in qid: Q24297991
retrieved: 2017-10-17

source: Solution Structure of the C-terminal Domain of the Ciliary Neurotrophic Factor (CNTF) Receptor and Ligand Free Associations among Components of the CNTF Receptor Complex
stated in qid: Q24300314
retrieved: 2017-10-17

source: WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27
stated in qid: Q24307411
retrieved: 2019-04-08

source: Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF
stated in qid: Q24297991
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2017-10-17

source: LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor
stated in qid: Q24315815
retrieved: 2019-04-08

source: Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
stated in qid: Q24306425
retrieved: 2017-10-17

source: Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation
stated in qid: Q24313382
retrieved: 2019-04-08

source: Molecular cloning and expression of an IL-6 signal transducer, gp130
stated in qid: Q24328945
retrieved: 2017-10-17

source: The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6
stated in qid: Q24290231
retrieved: 2019-04-08

source: Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex
stated in qid: Q27652013
retrieved: 2019-04-08

source: Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma
stated in qid: Q37554449
retrieved: 2019-04-08

source: The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling
stated in qid: Q28119167
retrieved: 2019-04-08

source: Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130
stated in qid: Q27642282
retrieved: 2019-04-08

source: Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling
stated in qid: Q24290902
retrieved: 2019-04-08

source: Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation
stated in qid: Q24319880
retrieved: 2019-04-08

source: Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation
stated in qid: Q24318667
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Molecular cloning and expression of an IL-6 signal transducer, gp130
stated in qid: Q24328945
retrieved: 2019-04-08

source: Solution Structure of the C-terminal Domain of the Ciliary Neurotrophic Factor (CNTF) Receptor and Ligand Free Associations among Components of the CNTF Receptor Complex
stated in qid: Q24300314
retrieved: 2019-04-08

source: Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
stated in qid: Q24306425
retrieved: 2019-04-08

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2017-10-17

source: Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
stated in qid: Q24313258
retrieved: 2017-10-17

source: Defining the membrane proteome of NK cells
stated in qid: Q24323157
retrieved: 2017-10-17

source: Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
stated in qid: Q24311654
retrieved: 2017-10-17

source: Defining the membrane proteome of NK cells
stated in qid: Q24323157
retrieved: 2019-04-08

source: In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
stated in qid: Q24337415
retrieved: 2019-04-08

source: Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes
stated in qid: Q22253414
retrieved: 2019-04-08

wikidata id: Q21116066
domain: protein
level: standard
html url: https://4ort.xyz/entity/interleukin-6-signal-transducer
markdown url: https://4ort.xyz/entity/interleukin-6-signal-transducer.md
facts url summary: https://4ort.xyz/entity/interleukin-6-signal-transducer/facts.json
facts url standard: https://4ort.xyz/entity/interleukin-6-signal-transducer/facts.json
facts url full: https://4ort.xyz/entity/interleukin-6-signal-transducer/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-09T11:45:35.016959Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-04-11T00:08:46.538879+00:00Z