# Interleukin 6 signal transducer

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116066](https://www.wikidata.org/wiki/Q21116066)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Glycoprotein_130)  
**Source**: https://4ort.xyz/entity/interleukin-6-signal-transducer


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P40189)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
5. [Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
6. [Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
7. [Solution Structure of the C-terminal Domain of the Ciliary Neurotrophic Factor (CNTF) Receptor and Ligand Free Associations among Components of the CNTF Receptor Complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
8. [WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
9. [Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
11. [LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
12. [Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
13. [Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
14. [Molecular cloning and expression of an IL-6 signal transducer, gp130](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
15. [The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
16. [Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
17. [Biochemical and functional analyses of gp130 mutants unveil JAK1 as a novel therapeutic target in human inflammatory hepatocellular adenoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
18. [The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
19. [Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
20. [Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
21. [Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
22. [Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
24. [Molecular cloning and expression of an IL-6 signal transducer, gp130](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
25. [Solution Structure of the C-terminal Domain of the Ciliary Neurotrophic Factor (CNTF) Receptor and Ligand Free Associations among Components of the CNTF Receptor Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
26. [Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
27. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
28. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
29. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
30. [Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
31. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
32. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
33. [Signal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
34. [Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
35. [WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27](http://www.ebi.ac.uk/QuickGO/annotations?protein=P40189&geneProductId=UniProtKB:P40189)
36. [Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40189)
37. Ensembl Release 99
38. UMLS 2023
39. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)