# Interleukin 6

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28563066](https://www.wikidata.org/wiki/Q28563066)  
**Source**: https://4ort.xyz/entity/interleukin-6-q28563066


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P20607)
3. Q20641742
4. [Binding Sites for Interleukin-6 in the Anterior Pituitary Gland](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
6. [Activation of the JAK-STAT signaling pathway in the rat basilar artery after subarachnoid hemorrhage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
7. [Neuroprotective effects of interleukin-6 on NMDA-induced rat retinal damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
8. [Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
9. [Proinflammatory cytokines expression in noise-induced damaged cochlea](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
10. [Probiotic agent Saccharomyces boulardii reduces the incidence of lung injury in acute necrotizing pancreatitis induced rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
11. [Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
12. [Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
13. [Influence of age on susceptibility to Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in Long-Evans rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
14. [Antigen-Presenting Dendritic Cells as Regulators of the Growth of Thyrocytes: A Role of Interleukin-1β and Interleukin-6*](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
15. [Pre-existing lipopolysaccharide may increase the risk of heatstroke in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
16. [Post-ischemic hypothermia for 24h in P7 rats rescues hippocampal neuron: association with decreased astrocyte activation and inflammatory cytokine expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
17. [Sustained reversal of diabetes following islet transplantation to striated musculature in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
18. [Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myocardium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
19. [Effect of Bacillus subtilis PB6, a natural probiotic on colon mucosal inflammation and plasma cytokines levels in inflammatory bowel disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
20. [Skeletal muscle growth in young rats is inhibited by chronic exposure to IL-6 but preserved by concurrent voluntary endurance exercise](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
21. [TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
22. [Soluble factors from rat basophilic leukemia (RBL-2H3) cells stimulated cooperatively the neurite outgrowth of PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
23. [Effect of 5-FU on modulation of disarrangement of immune-associated cytokines in experimental acute pancreatitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
24. [Identification of genes and proteins specifically regulated by costimulation of mast cell Fcε Receptor I and chemokine receptor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
25. [Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
26. [A High-Fat Diet Increases IL-1, IL-6, and TNF-α Production by Increasing NF-κB and Attenuating PPAR-γ Expression in Bone Marrow Mesenchymal Stem Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
27. [Ozonated water improves lipopolysaccharide-induced responses of an odontoblast-like cell line.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
28. [Signaling pathways and mediators in LPS-induced lung inflammation in diabetic rats: role of insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
29. [Neutralization of IL-10 exacerbates cycloheximide-induced hepatocellular apoptosis and necrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
30. [Analysis of gene expression profiles in tympanic membrane following perforation using PCR Array in rats--preliminary investigation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
31. [Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
32. [Prophylactic maternal n-acetylcysteine before lipopolysaccharide suppresses fetal inflammatory cytokine responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
33. [Interleukin-6 alters sleep of rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
34. [Interleukin 6 mediated differentiation and rescue of cell redox in PC12 cells exposed to ionizing radiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
35. [Glucagon-stimulated but not isoproterenol-stimulated glucose formation inhibition by interleukin-6 in primary cultured rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
36. [Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
37. [TLR2/NFκB signalling regulates endogenous IL-6 release from marrow-derived mesenchymal stromal cells to suppress the apoptosis of PC12 cells injured by oxygen and glucose deprivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
38. [AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
39. [Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
40. [Patterns and localization of gene expression during intramembranous bone regeneration in the rat femoral marrow ablation model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
41. [Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
42. [A new regulation of IL-6 production in adult cardiomyocytes by beta-adrenergic and IL-1 beta receptors and induction of cellular hypertrophy by IL-6 trans-signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
43. [Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
44. [Oxidative stress stimulates IL-4 and IL-6 production in mast cells by an APE/Ref-1-dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
45. [Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
46. [Oncostatin-M: a new bone active cytokine that activates osteoblasts and inhibits bone resorption](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
47. [Induction and regulation of interleukin-6 gene expression in rat astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
48. [The expression of interleukin-6 (IL-6), IL-6 receptor, and gp130-kilodalton glycoprotein in the rat decidua and a decidual cell line: regulation by 17beta-estradiol and prolactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20607)
49. ensembl Release 104