# Interleukin 6

> mammalian protein found in Mus musculus

**Wikidata**: [Q14865240](https://www.wikidata.org/wiki/Q14865240)  
**Source**: https://4ort.xyz/entity/interleukin-6-q14865240


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08505)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
5. [Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
6. [Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
7. [Induction of endogenous retroviral gene product (SU) as an acute-phase protein by IL-6 in murine hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
8. [A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
9. [Expression of the murine interleukin 6 receptor in hepatoma cells: the intracytoplasmic domain is not required for interleukin 6 signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
10. [Conservation of structure and function between human and murine IL-16](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
11. [Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
12. [Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
13. [Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
14. [MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
15. [Endocrine regulation of energy metabolism by the skeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
16. [An Extraribosomal Function of Ribosomal Protein L13a in Macrophages Resolves Inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
17. [Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
18. [Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
19. [Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
20. [Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
21. [The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
22. [Altered cytokine production in mice lacking P2X(7) receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
23. [CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
24. [Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
25. [Accessory protein-like is essential for IL-18-mediated signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
26. [Negative regulation of Toll-like-receptor signaling by IRF-4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
27. [Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
28. [The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
29. [RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
30. [Critical role of NOD2 in regulating the immune response to Staphylococcus aureus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
31. [Adenosine receptors in regulation of dendritic cell differentiation and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
32. [Interleukin-6 and cachexia in ApcMin/+ mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
33. [Interleukin-6 regulates pancreatic alpha-cell mass expansion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
34. [NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
35. [Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
36. [Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
37. [Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
38. [Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
39. [Hepatocyte Growth Factor Modulates Interleukin-6 Production in Bone Marrow Derived Macrophages: Implications for Inflammatory Mediated Diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
40. [The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
41. [Immunomodulatory effects associated with a live vaccine against Leishmania major containing CpG oligodeoxynucleotides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
42. [Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
43. [The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
44. [NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
45. [Inhibition of Th2 differentiation and GATA-3 expression by BCL-6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
46. [SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
47. [Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
48. [Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
49. [Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)
50. [Interleukin-6 deficiency increases inflammatory bone destruction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08505)