# Interleukin 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2007868](https://www.wikidata.org/wiki/Q2007868)  
**Source**: https://4ort.xyz/entity/interleukin-4-q2007868


## References

1. ensembl Release 106
2. UniProt
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P05112)
4. Q20641742
5. Freebase Data Dumps. 2013
6. [The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
7. [Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
9. [Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
10. [Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
11. [Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
12. [Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
13. [Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
14. [Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
15. [IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
16. [Galectin-9 induces maturation of human monocyte-derived dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
17. [Inflammatory cytokines (IL-4, IL-5 and IL-13)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
18. [IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
19. [LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
20. [B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
21. [Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-γ](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
22. [Interleukin-4 deficiency promotes gallstone formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
23. [CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
24. [Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
25. [Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05112)
26. ensembl Release 105
27. Ensembl Release 99