# Interleukin 23 subunit alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21120657](https://www.wikidata.org/wiki/Q21120657)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Interleukin_23_subunit_alpha)  
**Source**: https://4ort.xyz/entity/interleukin-23-subunit-alpha


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2108681)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9NPF7)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NPF7&geneProductId=UniProtKB:Q9NPF7)
7. [Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NPF7&geneProductId=UniProtKB:Q9NPF7)
8. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
9. [A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
10. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
11. [Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
12. [The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
13. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
14. [IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
15. [Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
16. [Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
17. [IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
18. [ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
19. [IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
20. [IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
21. [Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
22. [A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NPF7&geneProductId=UniProtKB:Q9NPF7)
23. [Regulation of virus-induced IL-12 and IL-23 expression in human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
24. [IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NPF7)
25. Ensembl Release 99