interleukin 21
type: Thing
alternate name: interleukin-21 isoform
alternate name: IL21
alternate name: interleukin-21
alternate name: Za11
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: four-helical cytokine-like, core
additional property: PropertyValue
  property ID: P486
  value: D000098546
additional property: PropertyValue
  property ID: P637
  value: NP_001193935
additional property: PropertyValue
  property ID: P637
  value: NP_068575
additional property: PropertyValue
  property ID: P638
  value: 2OQP
additional property: PropertyValue
  property ID: P638
  value: 3TGX
additional property: PropertyValue
  property ID: P646
  value: /m/026dqjz
additional property: PropertyValue
  property ID: P672
  value: D12.644.276.374.465.027
additional property: PropertyValue
  property ID: P672
  value: D12.776.467.374.465.027
additional property: PropertyValue
  property ID: P672
  value: D23.529.374.465.162
additional property: PropertyValue
  property ID: P680
  value: cytokine activity
additional property: PropertyValue
  property ID: P680
  value: interleukin-2 receptor binding
additional property: PropertyValue
  property ID: P680
  value: cytokine receptor binding
additional property: PropertyValue
  property ID: P681
  value: intracellular anatomical structure
additional property: PropertyValue
  property ID: P681
  value: extracellular space
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P682
  value: positive regulation of inflammatory response
additional property: PropertyValue
  property ID: P682
  value: positive regulation of cytokine production
additional property: PropertyValue
  property ID: P682
  value: cell maturation
additional property: PropertyValue
  property ID: P692
  value: PBB GE IL21 221271 at fs.png
additional property: PropertyValue
  property ID: P702
  value: IL21
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000477555
additional property: PropertyValue
  property ID: P705
  value: ENSP00000497915
additional property: PropertyValue
  property ID: P2892
  value: C0962190
additional property: PropertyValue
  property ID: P6366
  value: 129374314
additional property: PropertyValue
  property ID: P10283
  value: C129374314
confidence:
  popularity graph score:
    score: 0.012
    score pct: 1
    tier: established
    components:
      sitelinks: 11
      sitelinks norm: 0.026
      unique citations: 19
      unique citations norm: 0.007
      monthly pageviews: 68
      monthly pageviews norm: 0.0
  sitelinks: 11
  unique citations: 19
  monthly pageviews: 68
  yearly pageviews: 136
  pageview trend:
    m: 2026-08
    v: 68
  pageview trend:
    m: 2026-07
    v: 11
  pageview trend:
    m: 2026-06
    v: 19
  pageview trend:
    m: 2026-05
    v: 4
  pageview trend:
    m: 2026-05
    v: 3
  pageview trend:
    m: 2026-05
    v: 1
  pageview trend:
    m: 2026-05
    v: 7
  pageview trend:
    m: 2026-04
    v: 23
  popularity:
    sitelinks: 11
    max: 423
    pct: 2.6
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9HBE4
    source count: 1
    confidence: 0.2
  P361:
    value: Q24724363
    source count: 1
    confidence: 0.2
    value label: four-helical cytokine-like, core
  P486:
    value: D000098546
    source count: 0
    confidence: 0.0
  P637:
    value: NP_001193935
    source count: 1
    confidence: 0.2
  P637:
    value: NP_068575
    source count: 1
    confidence: 0.2
  P638:
    value: 2OQP
    source count: 1
    confidence: 0.2
  P638:
    value: 3TGX
    source count: 1
    confidence: 0.2
  P646:
    value: /m/026dqjz
    source count: 1
    confidence: 0.2
  P672:
    value: D12.644.276.374.465.027
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.467.374.465.027
    source count: 0
    confidence: 0.0
  P672:
    value: D23.529.374.465.162
    source count: 0
    confidence: 0.0
  P680:
    value: Q14862699
    source count: 1
    confidence: 0.2
    value label: cytokine activity
  P680:
    value: Q14864499
    source count: 1
    confidence: 0.2
    value label: interleukin-2 receptor binding
  P680:
    value: Q14865952
    source count: 2
    confidence: 0.4
    value label: cytokine receptor binding

value: Q3824358
source count: 1
confidence: 0.2
value label: intracellular anatomical structure

value: Q1385443
source count: 3
confidence: 0.6
value label: extracellular space

value: Q14645596
source count: 3
confidence: 0.6
value label: extracellular region

value: Q14859639
source count: 1
confidence: 0.2
value label: positive regulation of inflammatory response

value: Q14851900
source count: 1
confidence: 0.2
value label: positive regulation of cytokine production

value: Q14859575
source count: 1
confidence: 0.2
value label: cell maturation

value: Q14863401
source count: 1
confidence: 0.2
value label: positive regulation of B cell proliferation

value: Q14864507
source count: 1
confidence: 0.2
value label: positive regulation of tissue remodeling

value: PBB GE IL21 221271 at fs.png
source count: 0
confidence: 0.0

value: Q14907210
source count: 1
confidence: 0.2
value label: IL21

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000477555
source count: 1
confidence: 0.2

value: ENSP00000497915
source count: 1
confidence: 0.2

value: C0962190
source count: 1
confidence: 0.2

value: 129374314
source count: 0
confidence: 0.0

value: C129374314
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain
stated in qid: Q24337739
retrieved: 2019-04-08

source: Biology of IL-21 and the IL-21 receptor
stated in qid: Q24315354
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-09-10

source: Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
stated in qid: Q24290522
retrieved: 2019-04-08

source: Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells
stated in qid: Q24304986
retrieved: 2019-04-08

source: Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease
stated in qid: Q24309586
retrieved: 2019-04-08

source: IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors
stated in qid: Q24300426
retrieved: 2019-04-08

source: Cloning and characterization of an isoform of interleukin-21
stated in qid: Q24336015
retrieved: 2019-04-08

source: Cloning and expression of human interleukin-21 cDNA in E.coli
stated in qid: Q24297319
retrieved: 2019-04-08

source: Interleukin-21 activates human natural killer cells and modulates their surface receptor expression
stated in qid: Q24300519
retrieved: 2019-04-08

source: IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response
stated in qid: Q24307467
retrieved: 2019-04-08

source: OpenAlex
stated in qid: Q107507571
retrieved: 2022-01-26

source: InterPro Release 71.0
stated in qid: Q58943792

source: Freebase Data Dumps
stated in qid: Q15241312
pub year: 2013

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: UMLS 2023
stated in qid: Q118645236
retrieved: 2023-05-25

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q909381
domain: protein
level: standard
html url: https://4ort.xyz/entity/interleukin-21
markdown url: https://4ort.xyz/entity/interleukin-21.md
facts url summary: https://4ort.xyz/entity/interleukin-21/facts.json
facts url standard: https://4ort.xyz/entity/interleukin-21/facts.json
facts url full: https://4ort.xyz/entity/interleukin-21/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-23T18:25:41.959411Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-04-10T23:42:04.803876+00:00Z