# interleukin 21

> mammalian protein found in Homo sapiens

**Wikidata**: [Q909381](https://www.wikidata.org/wiki/Q909381)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Interleukin_21)  
**Source**: https://4ort.xyz/entity/interleukin-21


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9HBE4)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
6. [Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
7. [Biology of IL-21 and the IL-21 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HBE4&geneProductId=UniProtKB:Q9HBE4)
9. [Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
10. [Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
11. [Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
12. [IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
13. [Cloning and characterization of an isoform of interleukin-21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
14. [Cloning and expression of human interleukin-21 cDNA in E.coli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
15. [Interleukin-21 activates human natural killer cells and modulates their surface receptor expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
16. [IL-21 up-regulates the expression of genes associated with innate immunity and Th1 response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HBE4)
17. Ensembl Release 99
18. UMLS 2023
19. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)