# Interleukin 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q14864519](https://www.wikidata.org/wiki/Q14864519)  
**Source**: https://4ort.xyz/entity/interleukin-2-q14864519


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04351)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
5. [Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
6. [Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
7. [Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
8. [IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
9. [Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
10. [Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
11. [The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
12. [Altered Antigen Presentation in Mice Lacking H2-O](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
13. [Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
14. [The specificity and orientation of a TCR to its peptide-MHC class II ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
15. [Differential T cell costimulatory requirements in CD28-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
16. [Critical role of NOD2 in regulating the immune response to Staphylococcus aureus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
17. [Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
18. [Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
19. [ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
20. [FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
21. [A function for interleukin 2 in Foxp3-expressing regulatory T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
22. [Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
23. [The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
24. [Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin‐2‐deficient colitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
25. [Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
26. [MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
27. [IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04351)
28. ensembl Release 106