# Interleukin 18

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562618](https://www.wikidata.org/wiki/Q28562618)  
**Source**: https://4ort.xyz/entity/interleukin-18-q28562618


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P97636)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
5. [Rat interleukin-18 binding protein: cloning, expression, and characterization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
6. [Interleukin-18 is expressed in rat testis and may promote germ cell growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
7. [IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
8. [Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
9. [Evidence of IL-18 as a novel angiogenic mediator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
10. [Interleukin-18 is regulated by parathyroid hormone and is required for its bone anabolic actions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
11. [Interleukin-18 involvement in hypoxic-ischemic brain injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
12. [Neurons of the superior nucleus of the medial habenula and ependymal cells express IL-18 in rat CNS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
13. [Shock wave therapy effectively attenuates inflammation in rat carotid artery following endothelial denudation by balloon catheter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
14. [Induction of interferon-gamma inducing factor in the adrenal cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
15. [Angiotensin II enhances AT1-Nox1 binding and stimulates arterial smooth muscle cell migration and proliferation through AT1, Nox1, and interleukin-18.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
16. [A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
17. [Global and gene-specific translational regulation in rat lung development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
18. [Interleukin-18 promotes sleep in rabbits and rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
19. [Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
20. [The effects of interleukin-18 on rat articular chondrocytes: a study of mRNA expression and protein synthesis of proinflammatory substances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
21. [Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: effect of TNF-alpha and IFN-gamma treatment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
22. [Overexpression of interleukin-18 aggravates cardiac fibrosis and diastolic dysfunction in fructose-fed rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
23. [Interleukin-18 Delays Neutrophil Apoptosis following Alcohol Intoxication and Burn Injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
24. [Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
25. [Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
26. [Role of IL-18 in Acute Lung Inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
27. [Tissue-specific expression of rat IL-18 gene and response to adrenocorticotropic hormone treatment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
28. [Activation of caspase-1 dependent interleukins in developmental brain trauma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
29. [Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
30. [The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
31. [Erythropoietin attenuates hyperoxia-induced cell death by modulation of inflammatory mediators and matrix metalloproteinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
32. [TNF-alpha and H2O2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
33. [Mechanical stretch induced interleukin-18 (IL-18) expression through Angiotensin subtype 1 receptor (AT1R) and endothelin-1 in cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
34. [Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
35. [Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97636)
36. ensembl Release 104