# Interleukin 18

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2657109](https://www.wikidata.org/wiki/Q2657109)  
**Source**: https://4ort.xyz/entity/interleukin-18-q2657109


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14116)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
6. [Structural basis for the specific recognition of IL‐18 by its alpha receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
7. [Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
8. [Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
10. [The structure and binding mode of interleukin-18](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
11. [The structural basis for receptor recognition of human interleukin-18](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
12. [Pro/Anti-Inflammatory Cytokines in the Pathogenesis of Premature Coronary Artery Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
13. [Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
14. [Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
15. [Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
16. [Regulation of Th1 and Th2 immune responses by IL-18](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
17. [IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
18. [Interleukin-18 promotes sleep in rabbits and rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
19. [A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
20. [Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
21. [Evidence of IL-18 as a novel angiogenic mediator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
22. [Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
23. [Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
24. [Interleukin‐18 may lead to benign prostatic hyperplasia via thrombospondin‐1 production in prostatic smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
25. [IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
26. [IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
27. [Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
28. [Role of TNF in mast cell neuroinflammation and pain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14116)
29. Ensembl Release 99