# Interleukin 12B

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21120640](https://www.wikidata.org/wiki/Q21120640)  
**Source**: https://4ort.xyz/entity/interleukin-12b


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2108681)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P29460)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
6. [Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
7. [Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460)
8. [Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460)
9. [Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460)
10. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
11. [A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
12. [Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
13. [Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
14. [Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
15. [The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
16. [Ovine interleukin 12 has biological activity on ovine and human activated peripheral blood mononuclear cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
17. [Ovine interleukin 12 has biological activity on ovine and human activated peripheral blood mononuclear cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
20. [Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
21. [Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
22. [Differential effects of IL12 and IL2 on expression and function of cellular adhesion molecules on purified human natural killer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
23. [IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
24. [Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
25. [Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
26. [Ovarian follicular concentration of IL-12, IL-15, IL-18 and p40 subunit of IL-12 and IL-23](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
27. [Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
28. [Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
29. [IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
30. [ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
31. [Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460)
32. [IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460)
33. [IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
34. [IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
35. [Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460)
36. [UVB induces IL-12 transcription in human keratinocytes in vivo and in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
37. [Regulation of virus-induced IL-12 and IL-23 expression in human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
38. [A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29460&geneProductId=UniProtKB:P29460)
39. [IL-23 promotes growth and proliferation in human squamous cell carcinoma of the oral cavity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29460)
40. Ensembl Release 99
41. UMLS 2023