# Interleukin 12b

> mammalian protein found in Mus musculus

**Wikidata**: [Q21984529](https://www.wikidata.org/wiki/Q21984529)  
**Source**: https://4ort.xyz/entity/interleukin-12b-q21984529


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P43432)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
5. [Development of Th1-type immune responses requires the type I cytokine receptor TCCR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
6. [Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
7. [NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
8. [Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
9. [Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
10. [Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
11. [Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue–inducer cell and NK cell lineages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
12. [Interferon Consensus Sequence Binding Protein–deficient Mice Display Impaired Resistance to Intracellular Infection Due to a Primary Defect in Interleukin 12 p40 Induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
13. [Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
14. [Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
15. [Negative regulation of Toll-like-receptor signaling by IRF-4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
16. [Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
17. [Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
18. [CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
19. [IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
20. [Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
21. [Accessory protein-like is essential for IL-18-mediated signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
22. [H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
23. [Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
24. [Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
25. [Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
26. [Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43432)
27. ensembl Release 106