# Interleukin 12A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21120636](https://www.wikidata.org/wiki/Q21120636)  
**Source**: https://4ort.xyz/entity/interleukin-12a-q21120636


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P29459)
3. Q20641742
4. [Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
6. [Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
7. [Epstein–Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
8. [Ovine interleukin 12 has biological activity on ovine and human activated peripheral blood mononuclear cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
9. [Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
10. [Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
11. [The human plasma proteome: a nonredundant list developed by combination of four separate sources](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
12. [Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
13. [Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
14. [Interleukin 5, IL6, IL12, IFN-gamma, RANTES and Fractalkine in human nasal polyps, turbinate mucosa and serum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
15. [Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
16. [Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
17. [IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
18. [Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
19. [Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
20. [Differential effects of IL12 and IL2 on expression and function of cellular adhesion molecules on purified human natural killer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
21. [Interleukin 12 deficiency associated with recurrent infections](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
22. [UVB induces IL-12 transcription in human keratinocytes in vivo and in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
23. [Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
24. [Up‐regulation of galectin‐9 induces cell migration in human dendritic cells infected with dengue virus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
25. [Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
26. [The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29459)
27. Ensembl Release 99
28. UMLS 2023