# interleukin 10

> mammalian protein found in Homo sapiens

**Wikidata**: [Q423698](https://www.wikidata.org/wiki/Q423698)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Interleukin_10)  
**Source**: https://4ort.xyz/entity/interleukin-10


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P22301)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
6. [Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
7. [Structure and Mechanism of Receptor Sharing by the IL-10R2 Common Chain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
8. [Comparison of interleukin-22 and interleukin-10 soluble receptor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
9. [Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
10. [Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
11. [Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
13. [Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
14. [Pro/Anti-Inflammatory Cytokines in the Pathogenesis of Premature Coronary Artery Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
15. [IL-4 and IL-13 induce protection of porcine endothelial cells from killing by human complement and from apoptosis through activation of a phosphatidylinositide 3-kinase/Akt pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
16. [Interleukin-10 and the interleukin-10 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
17. [The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
18. [A novel regulatory B-cell population in sheep Peyer's patches spontaneously secretes IL-10 and downregulates TLR9-induced IFNalpha responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
19. [Human interleukin 10 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
20. [Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
21. [IL-10 inhibits apoptotic cell death in human T cells starved of IL-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
22. [Interleukin 10 (IL-10)-mediated inhibition of inflammatory cytokine production by human alveolar macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
23. [Interleukin-10 and the interleukin-10 receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22301&geneProductId=UniProtKB:P22301)
24. [Identification of functional domains on human interleukin 10](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
25. [Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
26. [Human interleukin-10 can directly inhibit T-cell growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
27. [Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
28. [Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
29. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22301&geneProductId=UniProtKB:P22301)
30. [Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
31. [B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
32. [Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
33. [IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
34. [WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22301)
35. ensembl Release 96
36. Identifiers.org
37. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)