# Interleukin 1 receptor associated kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173372](https://www.wikidata.org/wiki/Q21173372)  
**Source**: https://4ort.xyz/entity/interleukin-1-receptor-associated-kinase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P51617)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
5. [Identification and characterization of murine IRAK-M](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
6. [IRAK1b, a Novel Alternative Splice Variant of Interleukin-1 Receptor-associated Kinase (IRAK), Mediates Interleukin-1 Signaling and Has Prolonged Stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
7. [IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
8. [IRAK: A Kinase Associated with the Interleukin-1 Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
9. [An inflammatory bowel disease–risk variant in INAVA decreases pattern recognition receptor–induced outcomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
10. [PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
11. [Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
12. [Pellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
13. [IRAK-mediated Translocation of TRAF6 and TAB2 in the Interleukin-1-induced Activation of NFκB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
14. [Characterization of Pellino2, a substrate of IRAK1 and IRAK4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
15. [Pellino3, a Novel Member of the Pellino Protein Family, Promotes Activation of c-Jun and Elk-1 and May Act as a Scaffolding Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
16. [Hepatitis C Virus Nonstructural Protein 5A Modulates the Toll-Like Receptor-MyD88-Dependent Signaling Pathway in Macrophage Cell Lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
17. [Pellino 1 Is Required for Interleukin-1 (IL-1)-mediated Signaling through Its Interaction with the IL-1 Receptor-associated Kinase 4 (IRAK4)-IRAK-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
18. [Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
19. [Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
20. [The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
21. [Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon–mediated immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
22. [Pellino proteins are more than scaffold proteins in TLR/IL‐1R signalling: A role as novel RING E3–ubiquitin‐ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
23. [The CATERPILLER Protein Monarch-1 Is an Antagonist of Toll-like Receptor-, Tumor Necrosis Factor α-, and Mycobacterium tuberculosis-induced Pro-inflammatory Signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
24. [SIGIRR, a negative regulator of Toll-like receptor–interleukin 1 receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
25. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617)
26. [IRAK1b, a Novel Alternative Splice Variant of Interleukin-1 Receptor-associated Kinase (IRAK), Mediates Interleukin-1 Signaling and Has Prolonged Stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617)
27. [IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
30. [IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
31. [Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
32. [IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617)
33. [The IRAK-1-BCL10-MALT1-TRAF6-TAK1 Cascade Mediates Signaling to NF-κB from Toll-like Receptor 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
34. [The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617)
35. [HCV-Induced miR-21 Contributes to Evasion of Host Immune System by Targeting MyD88 and IRAK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
36. [The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
37. [Brain Endothelial miR-146a Negatively Modulates T-Cell Adhesion through Repressing Multiple Targets to Inhibit NF-κB Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617)
38. Ensembl Release 99