# Interleukin 1 receptor antagonist

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562749](https://www.wikidata.org/wiki/Q28562749)  
**Source**: https://4ort.xyz/entity/interleukin-1-receptor-antagonist-q28562749


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
4. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
5. [Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
6. [Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
7. [Interleukin-1 receptor antagonist as a modulator of gender differences in the febrile response to lipopolysaccharide in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
8. [Interleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the preoptic area of rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
9. [Interleukin-1beta mediates the memory impairment associated with a delayed type hypersensitivity response to bacillus Calmette-Guérin in the rat hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
10. [Influence of Pregnancy on Plasma Cytokines and the Febrile Response to Intraperitoneal Administration of Bacterial Endotoxin in Rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
11. [The bisphosphonate alendronate improves the damage associated with trinitrobenzenesulfonic acid-induced colitis in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
12. [Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
13. [Rosiglitazone induces interleukin-1 receptor antagonist in interleukin-1beta-stimulated rat synovial fibroblasts via a peroxisome proliferator-activated receptor beta/delta-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
14. [Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
15. [Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
16. [Kainic acid induced expression of interleukin-1 receptor antagonist mRNA in the rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
17. [Unmasking of LPA1 receptor‐mediated migration response to lysophosphatidic acid by interleukin‐1β‐induced attenuation of Rho signaling pathways in rat astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
18. [Attenuated mRNA expression of inflammatory mediators in neonatal rat lung following lipopolysaccharide treatment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
19. [Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
20. [Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
21. [Regulation of brain interleukin-1 beta (IL-1 beta) system mRNAs in response to pathophysiological concentrations of IL-1 beta in the cerebrospinal fluid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
22. [Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
23. [Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25086)
24. ensembl Release 104