# Interleukin 1 beta

> mammalian protein found in Mus musculus

**Wikidata**: [Q14916414](https://www.wikidata.org/wiki/Q14916414)  
**Source**: https://4ort.xyz/entity/interleukin-1-beta-q14916414


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P10749)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
6. [The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
7. [Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
8. [Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749)
9. [Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749)
11. [Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749)
12. [Altered cytokine production in mice lacking P2X(7) receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749)
13. [Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749)
14. [Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749)
15. [A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749)
16. [Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
17. [Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
18. [Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
19. [Altered cytokine production in mice lacking P2X(7) receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
20. [A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
21. [Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
22. [Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
23. [An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
24. [Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749)
25. [Central control of fever and female body temperature by RANKL/RANK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
26. [IL-1 is required for tumor invasiveness and angiogenesis](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749)
27. [Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
28. [Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
29. [P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
30. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749)
31. [IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749)
32. [Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749)
33. [Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749)
34. [P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10749&geneProductId=UniProtKB:P10749)
35. [The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749)
36. [TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P10749)
37. [IL-1 is required for tumor invasiveness and angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
38. [IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
39. [Accessory protein-like is essential for IL-18-mediated signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
40. [Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
41. [TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
42. [Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
43. [Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
44. [Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10749)
45. ensembl Release 106