# Interferon regulatory factor 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5973468](https://www.wikidata.org/wiki/Q5973468)  
**Source**: https://4ort.xyz/entity/interferon-regulatory-factor-3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14653)
3. Q20641742
4. [Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
6. [Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14653&geneProductId=UniProtKB:Q14653)
8. [C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
9. [TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
10. [Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination-dependent Manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
11. [Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
12. [Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
13. [Crystal structure of IRF-3 in complex with CBP.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
14. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
15. [The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
16. [The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
17. [Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
18. [S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFN beta pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
19. [Interaction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
20. [The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
21. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
22. [Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
23. [RIOK3 Is an Adaptor Protein Required for IRF3-Mediated Antiviral Type I Interferon Production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
24. [Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
25. [A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
26. [Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
27. [Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14653&geneProductId=UniProtKB:Q14653)
28. [DNA-binding specificities of human transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
29. [ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
30. [MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
31. [Structural basis for suppression of a host antiviral response by influenza A virus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
32. [Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
33. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
34. [Activation of STAT6 by STING is critical for antiviral innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
35. [Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
36. [Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
37. [Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
38. [ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
39. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14653&geneProductId=UniProtKB:Q14653)
40. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
41. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
42. [STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
43. [The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
44. [Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
45. [The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14653&geneProductId=UniProtKB:Q14653)
46. [Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14653&geneProductId=UniProtKB:Q14653)
47. [Regulation of immunity and oncogenesis by the IRF transcription factor family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
48. [Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
49. [Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)
50. [Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14653)