# Interferon regulatory factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173368](https://www.wikidata.org/wiki/Q21173368)  
**Source**: https://4ort.xyz/entity/interferon-regulatory-factor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P10914)
3. Q20641742
4. [Swiss-Prot](http://www.uniprot.org/uniprot/P15314.txt?version=131)
5. [Activities of IRF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
7. [Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914)
8. [Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
9. [Regulation of XAF1 expression in human colon cancer cell by interferon beta: activation by the transcription regulator STAT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
10. [Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
11. [Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
12. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914)
14. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
16. [Activities of IRF-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10914&geneProductId=UniProtKB:P10914)
17. [IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
18. [Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
19. [IRF-1 as a negative regulator of cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
20. [Interferon Regulatory Factor 1 Transactivates Expression of Human DNA Polymerase η in Response to Carcinogen N-Methyl-N′-nitro-N-nitrosoguanidine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
21. [Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
22. [Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
23. [Expression of the Bcl-2 protein BAD promotes prostate cancer growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
24. [Human papillomavirus type 16 E5 protein induces expression of beta interferon through interferon regulatory factor 1 in human keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
25. [RNA interference of interferon regulatory factor-1 gene expression in THP-1 cell line leads to Toll-like receptor-4 overexpression/activation as well as up-modulation of annexin-II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10914)
26. Ensembl Release 99
27. UMLS 2023