# Interferon induced with helicase C domain 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111069](https://www.wikidata.org/wiki/Q21111069)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/MDA5)  
**Source**: https://4ort.xyz/entity/interferon-induced-with-helicase-c-domain-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9BYX4)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
5. [Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
6. [Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
7. [MDA5 is SUMOylated by PIAS2β in the upregulation of Type I interferon signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
8. [The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
9. [Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
10. [Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
11. [NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
12. [DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
13. [Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
14. [Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination-dependent Manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
15. [Mapping a dynamic innate immunity protein interaction network regulating type I interferon production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
16. [Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
17. [RIOK3-Mediated Phosphorylation of MDA5 Interferes with Its Assembly and Attenuates the Innate Immune Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
18. [Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
19. [A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
20. [ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
21. [Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
22. [IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
23. [Activation of MDA5 requires higher-order RNA structures generated during virus infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
24. [Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
25. [PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
26. [Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
27. [Immune signaling by RIG-I-like receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
28. [Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
29. [DHX9 Pairs with IPS-1 To Sense Double-Stranded RNA in Myeloid Dendritic Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4)
30. ensembl Release 93
31. UMLS 2023
32. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)