Interferon gamma
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P01579
additional property: PropertyValue
  property ID: P361
  value: interferon gamma
additional property: PropertyValue
  property ID: P361
  value: four-helical cytokine-like, core
additional property: PropertyValue
  property ID: P637
  value: NP_000610
additional property: PropertyValue
  property ID: P638
  value: 1EKU
additional property: PropertyValue
  property ID: P638
  value: 1FG9
additional property: PropertyValue
  property ID: P638
  value: 1FYH
additional property: PropertyValue
  property ID: P680
  value: interferon-gamma receptor binding
additional property: PropertyValue
  property ID: P680
  value: cytokine activity
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: external side of plasma membrane
additional property: PropertyValue
  property ID: P681
  value: perikaryon
additional property: PropertyValue
  property ID: P682
  value: apoptotic process
additional property: PropertyValue
  property ID: P682
  value: positive regulation of MHC class II biosynthetic process
additional property: PropertyValue
  property ID: P682
  value: negative regulation of smooth muscle cell proliferation
additional property: PropertyValue
  property ID: P702
  value: IFNG
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000229135
confidence:
  popularity graph score:
    score: 0.007
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 48
      unique citations norm: 0.019
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 48
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P01579
    source count: 1
    confidence: 0.2
  P361:
    value: Q24741149
    source count: 1
    confidence: 0.2
    value label: interferon gamma
  P361:
    value: Q24724363
    source count: 1
    confidence: 0.2
    value label: four-helical cytokine-like, core
  P637:
    value: NP_000610
    source count: 1
    confidence: 0.2
  P638:
    value: 1EKU
    source count: 1
    confidence: 0.2
  P638:
    value: 1FG9
    source count: 1
    confidence: 0.2
  P638:
    value: 1FYH
    source count: 1
    confidence: 0.2
  P638:
    value: 1HIG
    source count: 1
    confidence: 0.2
  P638:
    value: 3BES
    source count: 1
    confidence: 0.2
  P680:
    value: Q21111407
    source count: 2
    confidence: 0.4
    value label: interferon-gamma receptor binding
  P680:
    value: Q14862699
    source count: 2
    confidence: 0.4
    value label: cytokine activity
  P680:
    value: Q167149
    source count: 3
    confidence: 0.6
    value label: protein binding
  P681:
    value: Q14645596
    source count: 4
    confidence: 0.8
    value label: extracellular region
  P681:
    value: Q14633850
    source count: 1
    confidence: 0.2
    value label: external side of plasma membrane
  P681:
    value: Q842429
    source count: 1
    confidence: 0.2
    value label: perikaryon
  P681:
    value: Q14645640
    source count: 1
    confidence: 0.2
    value label: neuron projection
  P681:
    value: Q79899
    source count: 1
    confidence: 0.2
    value label: cytoplasm
  P682:
    value: Q14599311
    source count: 1
    confidence: 0.2
    value label: apoptotic process
  P682:
    value: Q14864458
    source count: 1
    confidence: 0.2
    value label: positive regulation of MHC class II biosynthetic process
  P682:
    value: Q14818124
    source count: 1
    confidence: 0.2
    value label: negative regulation of smooth muscle cell proliferation
  P682:
    value: Q21173276
    source count: 1
    confidence: 0.2
    value label: cellular response to interleukin-18
  P682:
    value: Q14876119
    source count: 1
    confidence: 0.2
    value label: antigen processing and presentation
  P702:
    value: Q18027639
    source count: 1
    confidence: 0.2
    value label: IFNG

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000229135
source count: 1
confidence: 0.2

source: Selective diapedesis of Th1 cells induced by endothelial cell RANTES
stated in qid: Q22010520
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Structure and mechanism of IFN- antagonism by an orthopoxvirus IFN- -binding protein
stated in qid: Q27649793
retrieved: 2019-05-09

source: Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor
stated in qid: Q28293731
retrieved: 2019-05-09

source: The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex
stated in qid: Q27630649
retrieved: 2019-05-09

source: Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels
stated in qid: Q24293495
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2017-10-17

source: Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death
stated in qid: Q24310279
retrieved: 2019-05-09

source: Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis
stated in qid: Q24301111
retrieved: 2019-05-09

source: HIV-1 p17 and IFN-γ Both Induce Fructose 1,6-Bisposphatase
stated in qid: Q24308813
retrieved: 2019-05-09

source: IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL
stated in qid: Q24338171
retrieved: 2019-05-09

source: Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit
stated in qid: Q24316432
retrieved: 2017-10-17

source: Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
stated in qid: Q24317746
retrieved: 2017-10-17

source: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
stated in qid: Q24338801
retrieved: 2019-05-09

source: Deacetylation of p53 induces autophagy by suppressing Bmf expression
stated in qid: Q28510522
retrieved: 2019-05-09

source: Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans
stated in qid: Q24314701
retrieved: 2019-05-09

source: Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans
stated in qid: Q24314701
retrieved: 2017-10-17

source: The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons
stated in qid: Q24294462
retrieved: 2019-05-09

source: The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells
stated in qid: Q24315412
retrieved: 2019-05-09

source: Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-γ
stated in qid: Q24291880
retrieved: 2019-05-09

source: The killing of Leishmania major by human macrophages is mediated by nitric oxide induced after ligation of the Fc epsilon RII/CD23 surface antigen
stated in qid: Q24307697
retrieved: 2019-05-09

source: Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs
stated in qid: Q24338459
retrieved: 2017-10-17

source: The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons
stated in qid: Q24294462
retrieved: 2017-10-17

source: Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation
stated in qid: Q24297200
retrieved: 2019-04-08

source: Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation
stated in qid: Q24297200
retrieved: 2017-10-17

source: Intestinal epithelial cells secrete exosome-like vesicles
stated in qid: Q24291534
retrieved: 2017-10-17

source: A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection
stated in qid: Q24301928
retrieved: 2017-10-17

source: Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling
stated in qid: Q28910464
retrieved: 2017-10-17

source: A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection
stated in qid: Q24301928
retrieved: 2019-05-09

wikidata id: Q21173277
domain: protein
level: standard
html url: https://4ort.xyz/entity/interferon-gamma-q21173277
markdown url: https://4ort.xyz/entity/interferon-gamma-q21173277.md
facts url summary: https://4ort.xyz/entity/interferon-gamma-q21173277/facts.json
facts url standard: https://4ort.xyz/entity/interferon-gamma-q21173277/facts.json
facts url full: https://4ort.xyz/entity/interferon-gamma-q21173277/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T07:23:08.162013Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:50.900290+00:00Z