# integrin subunit beta 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2458503](https://www.wikidata.org/wiki/Q2458503)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Integrin_beta_2)  
**Source**: https://4ort.xyz/entity/integrin-subunit-beta-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P05107)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
7. [Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
8. [Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
9. [CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
10. [Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
11. [Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
12. [c-Abl kinase is required for beta 2 integrin-mediated neutrophil adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
13. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
14. [Cytoskeletal protein radixin activates integrin alpha(M)beta(2) by binding to its cytoplasmic tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
15. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
16. [Structure of an integrin with an αI domain, complement receptor type 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
17. [Requirement of open headpiece conformation for activation of leukocyte integrin αXβ2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
18. [Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
19. [Characterization of L‐plastin interaction with beta integrin and its regulation by micro‐calpain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
20. [Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
21. [A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
22. [Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
24. [Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
25. [Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
26. [Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
27. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
28. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
29. [Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
30. [A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
31. [Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
32. [Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunits](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
33. [CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
34. [The gene organisation of the human beta 2 integrin subunit (CD18)](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
35. [A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
36. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
37. [The gene organisation of the human beta 2 integrin subunit (CD18)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
38. [Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
39. [A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
40. [CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
41. [Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
42. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
43. [Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05107&geneProductId=UniProtKB:P05107)
44. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
45. [Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
46. [Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)
47. [Distinct mutations in two patients with leukocyte adhesion deficiency and their functional correlates](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05107&geneProductId=UniProtKB:P05107)
48. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05107&geneProductId=UniProtKB:P05107)
49. [Zymosan-induced IL-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet-activating factor as an autocrine modulator](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P05107)
50. [Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05107)