# Integrin subunit alpha L

> mammalian protein found in Homo sapiens

**Wikidata**: [Q3648604](https://www.wikidata.org/wiki/Q3648604)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Integrin_alpha_L)  
**Source**: https://4ort.xyz/entity/integrin-subunit-alpha-l


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P20701)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20701&geneProductId=UniProtKB:P20701)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
6. [Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
7. [Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
8. [Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
9. [Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
10. [Hepatitis C virus infection protein network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
11. [Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
12. [Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
13. [Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
14. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20701&geneProductId=UniProtKB:P20701)
15. [Disruption of the integrin alphaLbeta2 transmembrane domain interface by beta2 Thr-686 mutation activates alphaLbeta2 and promotes micro-clustering of the alphaL subunits](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20701&geneProductId=UniProtKB:P20701)
16. [Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20701&geneProductId=UniProtKB:P20701)
17. [A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20701&geneProductId=UniProtKB:P20701)
18. [Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
19. [Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
20. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P20701&geneProductId=UniProtKB:P20701)
21. [A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
22. [Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
23. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
24. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
25. [T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
26. [SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20701)
27. Ensembl Release 99
28. UMLS 2023
29. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)