# integrin subunit alpha 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4201951](https://www.wikidata.org/wiki/Q4201951)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Integrin_alpha_4)  
**Source**: https://4ort.xyz/entity/integrin-subunit-alpha-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P13612)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Propolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
6. [alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
7. [Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
8. [A family of beta 7 integrins on human mucosal lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
9. [Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
10. [Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
11. [Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
12. [Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
13. [Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
15. [JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
16. [Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α₄β₇](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
17. [Integrins αvβ3 and α4β1 Act as Coreceptors for Fractalkine, and the Integrin-Binding Defective Mutant of Fractalkine Is an Antagonist of CX3CR1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
18. [Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612)
20. [Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612)
21. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612)
22. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612)
23. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612)
24. [CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
25. [Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
26. [Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
27. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
28. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
29. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
30. [Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
31. [Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
32. [CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow](http://www.ebi.ac.uk/QuickGO/annotations?protein=P13612&geneProductId=UniProtKB:P13612)
33. [beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
34. [MiR-30s Family Inhibit the Proliferation and Apoptosis in Human Coronary Artery Endothelial Cells Through Targeting the 3'UTR Region of ITGA4 and PLCG1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13612)
35. Ensembl Release 99
36. UMLS 2023