# integrin subunit alpha 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q4201948](https://www.wikidata.org/wiki/Q4201948)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Integrin_alpha_2)  
**Source**: https://4ort.xyz/entity/integrin-subunit-alpha-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P17301)
3. Q20641742
4. [Angiogenesis promoted by vascular endothelial growth factor: Regulation through α1β1and α2β1 integrins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
5. [alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
7. [An RGD motif present in cadherin 17 induces integrin activation and tumor growth](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301)
8. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301)
9. [An RGD motif present in cadherin 17 induces integrin activation and tumor growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
10. [Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
11. [Evidence for the location of a binding sequence for the α2β1 integrin of endothelial cells, in the β1 subunit of laminin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
12. [Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
13. [Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
14. [Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
15. [SHARPIN is an endogenous inhibitor of β1-integrin activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
16. [Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
17. [Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
18. [Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
19. [Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
20. [Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
21. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301)
22. [alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301)
23. [Localization of the gene encoding the alpha 2 subunit of the human VLA-2 receptor to chromosome 5q23-31](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
24. [The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
25. [The Androgen Receptor Induces Integrin α6β1 to Promote Prostate Tumor Cell Survival via NF-κB and Bcl-xL Independently of PI3K Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
26. [Platelet Proteome Analysis Reveals Integrin-dependent Aggregation Defects in Patients with Myelodysplastic Syndromes](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301)
27. [Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301)
28. [Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301)
29. [Characterization of integrin engagement during defined human embryonic stem cell culture](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301)
30. [Quantitative proteomics identifies a Dab2/integrin module regulating cell migration](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301)
31. [The Androgen Receptor Induces Integrin α6β1 to Promote Prostate Tumor Cell Survival via NF-κB and Bcl-xL Independently of PI3K Signaling](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17301)
32. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
33. [Characterization of integrin engagement during defined human embryonic stem cell culture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
34. [Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
35. [Platelet Proteome Analysis Reveals Integrin-dependent Aggregation Defects in Patients with Myelodysplastic Syndromes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
36. [Quantitative proteomics identifies a Dab2/integrin module regulating cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
37. [Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
38. [Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
39. [Source](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
40. [Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
41. [Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17301)
42. Ensembl Release 99
43. UMLS 2023
44. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)