# insulin receptor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q422579](https://www.wikidata.org/wiki/Q422579)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Insulin_receptor)  
**Source**: https://4ort.xyz/entity/insulin-receptor


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2108964)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL575448)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P06213)
6. Q20641742
7. Freebase Data Dumps. 2013
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
9. [Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
10. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213)
11. [Insulin receptor: evidence that it is a protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
12. [Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
13. [Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213)
14. [Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213)
15. [Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06213)
16. [Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
17. [Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
18. [A fluorescent indicator for tyrosine phosphorylation-based insulin signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
19. [Direct interaction between ER membrane-bound PTP1B and its plasma membrane-anchored targets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
20. [Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
21. [Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
22. [The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
23. [Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
24. [An enzyme-linked immunosorbent assay to measure insulin receptor dephosphorylation by PTP1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
25. [Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
26. [PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
27. [The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
28. [Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
29. [Applying the SPOT peptide synthesis procedure to the study of protein tyrosine phosphatase substrate specificity: probing for the heavenly match in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
30. [The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
31. [The association of phosphoinositide 3‐kinase enhancer A with hepatic insulin receptor enhances its kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
32. [SH2-Bα is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
33. [Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
34. [Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
35. [Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
36. [Phosphorylation and activation of protein tyrosine phosphatase (PTP) 1B by insulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
37. [Monitoring the activation state of insulin/insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
38. [The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
39. [Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
40. [Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
41. [Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
42. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
43. [Regulation of protein tyrosine phosphatase 1B by sumoylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
44. [Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
45. [Comparative analysis of the signaling capabilities of the insulin receptor-related receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
46. [Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
47. [Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
48. [Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
49. [Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)
50. [Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06213)