# Insulin receptor substrate 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173765](https://www.wikidata.org/wiki/Q21173765)  
**Source**: https://4ort.xyz/entity/insulin-receptor-substrate-2


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
4. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
5. [Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
6. [Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
7. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
8. [Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
9. [The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4H2&geneProductId=UniProtKB:Q9Y4H2)
11. [Role of IRS-2 in insulin and cytokine signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4H2&geneProductId=UniProtKB:Q9Y4H2)
12. [Disruption of IRS-2 causes type 2 diabetes in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y4H2&geneProductId=UniProtKB:Q9Y4H2)
13. [siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
14. [Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
15. [Disruption of IRS-2 causes type 2 diabetes in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
16. [Role of IRS-2 in insulin and cytokine signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4H2)
17. Ensembl Release 99