# Insulin receptor substrate 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21986028](https://www.wikidata.org/wiki/Q21986028)  
**Source**: https://4ort.xyz/entity/insulin-receptor-substrate-2-q21986028


## References

1. UniProt
2. Q20641742
3. [Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
4. [CDK4 is an essential insulin effector in adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
5. [The Direct Involvement of SirT1 in Insulin-induced Insulin Receptor Substrate-2 Tyrosine Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
6. [Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
9. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
10. [Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122)
11. [Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
12. [Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival](http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122)
13. [Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
14. [Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
15. [Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human ?-cells from hyperglycemia-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
16. [Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
17. [Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
18. [The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth](http://www.ebi.ac.uk/QuickGO/annotations?protein=P81122&geneProductId=UniProtKB:P81122)
19. [The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P81122)
20. ensembl Release 106