# Insulin receptor substrate 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q1665322](https://www.wikidata.org/wiki/Q1665322)  
**Source**: https://4ort.xyz/entity/insulin-receptor-substrate-1


## References

1. UniProt
2. Q20641742
3. [Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
4. [Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
6. [Cloning and increased expression of an insulin receptor substrate - 1-like gene in human hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568)
7. [Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568)
9. [The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568)
10. [Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568)
11. [S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
12. [Insulin Receptor Substrate Proteins Create a Link between the Tyrosine Phosphorylation Cascade and the Ca2+-ATPases in Muscle and Heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
13. [Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
14. [The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
15. [Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
16. [Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
17. [Shc and CEACAM1 Interact to Regulate the Mitogenic Action of Insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
18. [Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
19. [Locating a protein-protein interaction in living cells via split Renilla luciferase complementation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
20. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
21. [Phospho-tyrosine dependent protein-protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
22. [Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
23. [SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
24. [Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
25. [Structure homology and interaction redundancy for discovering virus-host protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
26. [Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
27. [Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
28. [Split luciferase as an optical probe for detecting protein-protein interactions in mammalian cells based on protein splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
29. [A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
30. [Association of insulin receptor substrate 1 with simian virus 40 large T antigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
31. [Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
32. [Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
33. [Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
34. [Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
35. [Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568)
36. [Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568)
37. [Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
38. [Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
39. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
40. [The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
41. [Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
42. [Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
43. [siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
44. [siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568)
45. [Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
46. [Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
47. [Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
48. [Cloning and increased expression of an insulin receptor substrate - 1-like gene in human hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35568)
49. [Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568)
50. [Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35568&geneProductId=UniProtKB:P35568)