# Insulin receptor substrate 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28556221](https://www.wikidata.org/wiki/Q28556221)  
**Source**: https://4ort.xyz/entity/insulin-receptor-substrate-1-q28556221


## References

1. UniProt
2. Q20641742
3. [Phosphorylation of Ser357 of Rat Insulin Receptor Substrate-1 Mediates Adverse Effects of Protein Kinase C-δ on Insulin Action in Skeletal Muscle Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
5. [Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
7. [Insulin Receptor Substrate-1/SHP-2 Interaction, a Phenotype-dependent Switching Machinery of Insulin-like Growth Factor-I Signaling in Vascular Smooth Muscle Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
8. [Tumor Necrosis Factor (TNF)-α-induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-Iα Causes Insulin Resistance in 3T3-L1 Adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
9. [Insulin Receptor Substrate Proteins Create a Link between the Tyrosine Phosphorylation Cascade and the Ca2+-ATPases in Muscle and Heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
10. [A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
11. [Regulation of Insulin Receptor Substrate 1 Pleckstrin Homology Domain by Protein Kinase C: Role of Serine 24 Phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
12. [The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
13. [Protein-tyrosine Phosphatase-1B Negatively Regulates Insulin Signaling in L6 Myocytes and Fao Hepatoma Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
14. [Tyrosine Dephosphorylation and Deactivation of Insulin Receptor Substrate-1 by Protein-tyrosine Phosphatase 1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
15. [Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
16. [Englerin A Stimulates PKCθ to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
17. [The Fyn Tyrosine Kinase Binds Irs-1 and Forms a Distinct Signaling Complex during Insulin Stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
18. [Comparative analysis of the signaling capabilities of the insulin receptor-related receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
19. [53BP2S, Interacting with Insulin Receptor Substrates, Modulates Insulin Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
20. [Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
21. [The Role of the C-terminal Domain of Protein Tyrosine Phosphatase-1B in Phosphatase Activity and Substrate Binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
22. [Insulin receptor substrate‐1 (IRS‐1) forms a ribonucleoprotein complex associated with polysomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
23. [Mechanism for Differential Effect of Protein-Tyrosine Phosphatase 1B on AktVersusMitogen-Activated Protein Kinase in 3T3-L1 Adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
24. [Cloning and Characterization of PHIP, a Novel Insulin Receptor Substrate-1 Pleckstrin Homology DomainInteracting Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
25. [Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
26. [Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
27. [Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective Akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
28. [Protein Kinase C-ζ-induced Phosphorylation of Ser318 in Insulin Receptor Substrate-1 (IRS-1) Attenuates the Interaction with the Insulin Receptor and the Tyrosine Phosphorylation of IRS-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
29. [Effects of treadmill exercise and training frequency on anabolic signaling pathways in the skeletal muscle of aged rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
30. [Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
31. [Activation of the Insulin Receptor by Insulin and a Synthetic Peptide Leads to Divergent Metabolic and Mitogenic Signaling and Responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
32. [Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
33. [Caffeine modulates phosphorylation of insulin receptor substrate-1 and impairs insulin signal transduction in rat skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
34. [Blockade of IRS1 in isolated rat pancreatic islets improves glucose‐induced insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
35. [Pulsed electromagnetic fields rapidly modulate intracellular signaling events in osteoblastic cells: Comparison to parathyroid hormone and insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
36. [G-Protein and Tyrosine Kinase Receptor Cross-Talk in Rat Aortic Smooth Muscle Cells: Thrombin- and Angiotensin II-Induced Tyrosine Phosphorylation of Insulin Receptor Substrate-1 and Insulin-like Growth Factor 1 Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
37. [Interleukin-1β impairs brain derived neurotrophic factor-induced signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35570)
38. ensembl Release 106