# Insulin receptor substrate 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q15334111](https://www.wikidata.org/wiki/Q15334111)  
**Source**: https://4ort.xyz/entity/insulin-receptor-substrate-1-q15334111


## References

1. UniProt
2. Q20641742
3. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
4. [Subcellular Localization of Insulin Receptor Substrate Family Proteins Associated With Phosphatidylinositol 3-Kinase Activity and Alterations in Lipolysis in Primary Mouse Adipocytes From IRS-1 Null Mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
5. [Tumor Necrosis Factor (TNF)-α-induced Repression of GKAP42 Protein Levels through cGMP-dependent Kinase (cGK)-Iα Causes Insulin Resistance in 3T3-L1 Adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
6. [A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
7. [YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
8. [53BP2S, Interacting with Insulin Receptor Substrates, Modulates Insulin Signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
9. [Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
10. [The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
11. [Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
12. [Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
13. [Impaired liver regeneration in Nrf2 knockout mice: role of ROS‐mediated insulin/IGF‐1 resistance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
14. [Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase α](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
16. [Intracellular redistribution of nuclear and nucleolar proteins during differentiation of 32D murine hemopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
17. [Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
18. [The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
19. [Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
20. [Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35569&geneProductId=UniProtKB:P35569)
21. ensembl Release 106