# Insulin-like growth factor 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q14863723](https://www.wikidata.org/wiki/Q14863723)  
**Source**: https://4ort.xyz/entity/insulin-like-growth-factor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P05017)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
5. [Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
6. [The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
7. [Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
8. [Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
9. [Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05017&geneProductId=UniProtKB:P05017)
11. [Endocrine regulation of energy metabolism by the skeleton](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05017&geneProductId=UniProtKB:P05017)
12. [Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05017&geneProductId=UniProtKB:P05017)
13. [Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05017&geneProductId=UniProtKB:P05017)
14. [Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05017&geneProductId=UniProtKB:P05017)
15. [Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
16. [Endocrine regulation of energy metabolism by the skeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
17. [Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
18. [Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
19. [GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
20. [Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
21. [Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
22. [Nocturnin Suppresses Igf1 Expression in Bone by Targeting the 3′ Untranslated Region of Igf1 mRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
23. [Evidence that insulin-like growth factor I and growth hormone are required for prostate gland development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
24. [Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
25. [Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
26. [Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
27. [Insulin-like growth factor (IGF)-I controls prostate fibromuscular development: IGF-I inhibition prevents both fibromuscular and glandular development in eugonadal mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
28. [Loss of IGF-IEa or IGF-IEb Impairs Myogenic Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
29. [Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
30. [Akt promotes BMP2-mediated osteoblast differentiation and bone development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
31. [Liver-derived IGF1 enhances the androgenic response in prostate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
32. [Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05017&geneProductId=UniProtKB:P05017)
33. [ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
34. [Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
35. [Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
36. [PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
37. [Akt activation prevents Apop-1-induced death of cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
38. [Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
39. [Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
40. [Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
41. [Somatotroph and lactotroph changes in the adenohypophyses of mice with disrupted insulin-like growth factor I gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
42. [Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
43. [Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
44. [Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
45. [Myogenin protein stability is decreased by BMP-2 through a mechanism implicating Id1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
46. [Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
47. [A novel microglial subset plays a key role in myelinogenesis in developing brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05017)
48. ensembl Release 106
49. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)