# Insulin-like growth factor 1 receptor

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558619](https://www.wikidata.org/wiki/Q28558619)  
**Source**: https://4ort.xyz/entity/insulin-like-growth-factor-1-receptor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P24062)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
5. [Enhancement of AG1024-induced H9c2 cardiomyoblast cell apoptosis via the interaction of IGF2R with Galpha proteins and its downstream PKA and PLC-beta modulators by IGF-II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
6. [Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
8. [Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
9. [TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
10. [Aldosterone Induces Vascular Insulin Resistance by Increasing Insulin-Like Growth Factor-1 Receptor and Hybrid Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
11. [Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
12. [Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
13. [Astrocytes regulate the expression of insulin-like growth factor 1 receptor (IGF1-R) in primary cortical neurons during in vitro senescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
14. [Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor and its intervention by interleukin-10 in experimental hepatic fibrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
15. [Insulin-like growth factor-I activation of Akt survival cascade in neuronal cells requires the presence of its cognate receptor in caveolae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
16. [Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
17. [The Insulin-Like Growth Factor 1 Receptor Is Essential for Axonal Regeneration in Adult Central Nervous System Neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
18. [IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
19. [Disruption of growth hormone secretion alters Ca2+ current density and expression of Ca2+ channel and insulin-like growth factor genes in rat atria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
20. [Region-specific alterations in insulin-like growth factor receptor type I in the cerebral cortex and hippocampus of aged rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
21. [Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
22. [The effects of mesenchymal stem cells on c-kit up-regulation and cell-cycle re-entry of neonatal cardiomyocytes are mediated by activation of insulin-like growth factor 1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
23. [miR-194 Promotes Burn-Induced Hyperglycemia via Attenuating IGF-IR Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
24. [si-RNA inhibition of brain insulin or insulin-like growth factor receptors causes developmental cerebellar abnormalities: relevance to fetal alcohol spectrum disorder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
25. [The effects of induced type-I diabetes on developmental regulation of insulin & insulin like growth factor-1 (IGF-1) receptors in the cerebellum of rat neonates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
26. [Sex differences and left–right asymmetries in expression of insulin and insulin-like growth factor-1 receptors in developing rat hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
27. [Insulin-like growth factor-I receptor and estrogen receptor crosstalk mediates hormone-induced neurite outgrowth in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
28. [Fetal Programming of Gene Expression in Growth-Restricted Rats Depends on the Cause of Low Birth Weight](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
29. [Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
30. [Chromium improves protein deposition through regulating the mRNA levels of IGF-1, IGF-1R, and Ub in rat skeletal muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
31. [Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
32. [Shared pathways of osteoblast mitogenesis induced by amylin, adrenomedullin, and IGF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
33. [Nicotine-induced over-exposure to maternal glucocorticoid and activated glucocorticoid metabolism causes hypothalamic–pituitary–adrenal axis-associated neuroendocrine metabolic alterations in fetal rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
34. [Nicotine-induced retardation of chondrogenesis through down-regulation of IGF-1 signaling pathway to inhibit matrix synthesis of growth plate chondrocytes in fetal rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
35. [Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
36. [Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
37. [Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
38. [Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
39. [High levels of glucose induce apoptosis in cardiomyocyte via epigenetic regulation of the insulin-like growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
40. [Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome proliferator-activated receptor gamma2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
41. [Progesterone and dexamethasone differentially regulate the IGF-system in glial cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
42. [Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
43. [Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
44. [Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
45. [Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
46. [G-protein and tyrosine kinase receptor cross-talk in rat aortic smooth muscle cells: thrombin- and angiotensin II-induced tyrosine phosphorylation of insulin receptor substrate-1 and insulin-like growth factor 1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P24062)
47. ensembl Release 106