# insulin like growth factor 1 receptor

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2005209](https://www.wikidata.org/wiki/Q2005209)  
**Source**: https://4ort.xyz/entity/insulin-like-growth-factor-1-receptor-q2005209


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL575448)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL283120)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08069)
6. Q20641742
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
8. [Interaction of the .alpha..beta. dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
9. [Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
10. [Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
11. [Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
12. [Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
13. [Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
14. [14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
15. [Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
16. [JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
17. [{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
18. [Interaction of Human Suppressor of Cytokine Signaling (SOCS)-2 with the Insulin-like Growth Factor-I Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
19. [Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
20. [Localization of the Insulin-like Growth Factor I Receptor Binding Sites for the SH2 Domain Proteins p85, Syp, and GTPase Activating Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
21. [Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
22. [Fine Details of IGF-1R Activation, Inhibition, and Asymmetry Determined by Associated Hydrogen /Deuterium-Exchange and Peptide Mass Mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
23. [Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
24. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
25. [Interaction of SH2-containing protein tyrosine phosphatase 2 with the insulin receptor and the insulin-like growth factor-I receptor: studies of the domains involved using the yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
26. [Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
27. [Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
28. [Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
29. [Monitoring the activation state of insulin/insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
30. [Interaction of p85 subunit of PI 3‐kinase with insulin and IGF‐1 receptors analysed by using the two‐hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
31. [Hypoxia‐induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo‐ and radiation therapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
32. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
33. [Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
34. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
35. [Monitoring the activation state of the insulin-like growth factor-1 receptor and its interaction with protein tyrosine phosphatase 1B using bioluminescence resonance energy transfer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
36. [C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
37. [Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
38. [Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
39. [Intracellular association of a mutant insulin-like growth factor receptor with endogenous receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
40. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08069)
41. [Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08069)
42. [Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
43. [Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
44. [The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
45. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
46. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08069)
47. [Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3)](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08069)
48. [Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)
49. [Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P08069)
50. [Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08069)