# Insulin-like growth factor 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28561041](https://www.wikidata.org/wiki/Q28561041)  
**Source**: https://4ort.xyz/entity/insulin-like-growth-factor-1-q28561041


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08025)
3. Q20641742
4. [The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
6. [Inhibition of muscle insulin-like growth factor I expression by tumor necrosis factor-alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
7. [Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
8. [Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
9. [A graded model of dietary zinc deficiency: effects on growth, insulin-like growth factor-I, and the glucose/insulin axis in weanling rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
10. [Growth factors and glucose homeostasis in diabetic rats: effects of exercise training](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
11. [Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor and its intervention by interleukin-10 in experimental hepatic fibrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
12. [Megakaryocytes Endocytose Insulin-Like Growth Factor (IGF) I and IGF-Binding Protein-3: A Novel Mechanism Directing Them into α Granules of Platelets*](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
13. [Localization and function of insulin-like growth factor 1 in dorsal root ganglia in a rat disc herniation model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
14. [Changes in the expression of insulin-like growth factor 1 variants in the postnatal brain development and in neonatal hypoxia-ischaemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
15. [Evidence for suppression of immune function by insulin-like growth factor-1 in dwarf rats in vivo.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
16. [Disruption of growth hormone secretion alters Ca2+ current density and expression of Ca2+ channel and insulin-like growth factor genes in rat atria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
17. [Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
18. [Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
19. [Developmental changes in serum levels of free and total insulin-like growth factor I (IGF-I), IGF-binding protein-1 and -3, and the acid-labile subunit in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
20. [Effect of dietary proteins on the plasma immunoreactive insulin-like growth factor-1/somatomedin C concentration in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
21. [Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
22. [Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myocardium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
23. [Chronic exposure to perfluorododecanoic acid disrupts testicular steroidogenesis and the expression of related genes in male rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
24. [Cardiomyoblast apoptosis induced by insulin-like growth factor (IGF)-I resistance is IGF-II dependent and synergistically enhanced by angiotensin II.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
25. [Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat: Part 1: Effects on somatic growth, growth hormone-axis activity and bone mass in the offspring](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
26. [Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
27. [Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
28. [Effects of maternal undernutrition on lung growth and insulin-like growth factor system expression in rat offspring](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
29. [Daily rat tibial growth in vivo following hypothalamic sex reversal with neonatal and pubertal treatments with gonadal steroids](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
30. [Effects of lipopolysaccharide endotoxin on the insulin-like growth factor I system in rats with cirrhosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
31. [Chromium improves protein deposition through regulating the mRNA levels of IGF-1, IGF-1R, and Ub in rat skeletal muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
32. [Nicotine-induced retardation of chondrogenesis through down-regulation of IGF-1 signaling pathway to inhibit matrix synthesis of growth plate chondrocytes in fetal rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
33. [IGF-I and IGF-binding protein gene expressions in spontaneous dwarf rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
34. [The effect of insulin-like growth factor-I on hepatocyte apoptosis after bile duct ligation in rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
35. [MicroRNA-29 regulates myocardial microvascular endothelial cells proliferation and migration in association with IGF1 in type 2 diabetes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
36. [Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
37. [Insulin and insulin-like growth factor resistance with neurodegeneration in an adult chronic ethanol exposure model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
38. [Different effects of insulin and insulin-like growth factors I and II on osteoprogenitors and adipocyte progenitors in fetal rat bone cell populations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
39. [Effects of estradiol-17beta, testosterone and a black cohosh preparation on bone and prostate in orchidectomized rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
40. [Regulation of signaling pathways downstream of IGF-I/insulin by androgen in skeletal muscle of glucocorticoid-treated rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
41. [Insulin-like growth factor-1 modulation of CaV1.3 calcium channels depends on Ca2+ release from IP3-sensitive stores and calcium/calmodulin kinase II phosphorylation of the alpha1 subunit EF hand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
42. [Phospholipase D is a target for inhibition of astroglial proliferation by ethanol.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
43. [Radiometrical, hormonal and biological correlates of skeletal growth in the female rat from birth to senescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
44. [Increased IGF-I and IGF-II mRNA and IGF-I peptide in fusing rat cranial sutures suggest evidence for a paracrine role of insulin-like growth factors in suture fusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
45. [Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
46. [Suppression of insulin-like growth factor I during epidermal growth factor-induced growth retardation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
47. [Effect of electrical stimulation on IGF-1 transcription by L-type calcium channels in cultured retinal Müller cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
48. [Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
49. [Progesterone and dexamethasone differentially regulate the IGF-system in glial cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)
50. [Identification of IGF-I in the calvarial suture of young rats: histochemical analysis of the cranial sagittal sutures in a hyperthyroid rat model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08025)