# Insulin like growth factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q1263065](https://www.wikidata.org/wiki/Q1263065)  
**Source**: https://4ort.xyz/entity/insulin-like-growth-factor-1-q1263065


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P05019)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Hypothalamic/pituitary-axis of the spontaneous dwarf rat: autofeedback regulation of growth hormone (GH) includes suppression of GH releasing-hormone receptor messenger ribonucleic acid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
7. [Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
8. [Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
9. [Cross-talk between integrin α6β4 and insulin-like growth factor-1 receptor (IGF1R) through direct α6β4 binding to IGF1 and subsequent α6β4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
10. [The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
11. [Fine Details of IGF-1R Activation, Inhibition, and Asymmetry Determined by Associated Hydrogen /Deuterium-Exchange and Peptide Mass Mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
12. [Structural and Functional Analysis of HtrA1 and Its Subdomains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
13. [Structural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid Receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
14. [Structural basis for the regulation of insulin-like growth factors by IGF binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
15. [Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
16. [Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
17. [Both type I and II insulin-like growth factor receptor binding increase during lactogenesis in bovine mammary tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
18. [Stimulation of DNA synthesis in chicken muscle satellite cells by insulin and insulin-like growth factors: evidence for exclusive mediation by a type-I insulin-like growth factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
19. [The human plasma proteome: a nonredundant list developed by combination of four separate sources](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
20. [Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05019&geneProductId=UniProtKB:P05019)
22. [Induction of insulin-like growth factor 1 splice forms by subfragments of myofibrillar proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
23. [Ethnic disparity in the relationship between obesity and plasma insulin-like growth factors: the multiethnic cohort](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
24. [Early-age heat exposure affects skeletal muscle satellite cell proliferation and differentiation in chicks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
25. [Concerted regulation of the porcine steroidogenic acute regulatory protein gene promoter activity by follicle-stimulating hormone and insulin-like growth factor I in granulosa cells involves GATA-4 and CCAAT/enhancer binding protein beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
26. [Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
27. [Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
28. [Insulin-like Growth Factor-I Augments Erythropoietin-induced Proliferation through Enhanced Tyrosine Phosphorylation of STAT5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
29. [Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
30. [The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
31. [Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05019&geneProductId=UniProtKB:P05019)
32. [Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
33. [Insulin-like growth factor I induces proliferation and migration of porcine trophectoderm cells through multiple cell signaling pathways, including protooncogenic protein kinase 1 and mitogen-activated protein kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
34. [Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
35. [Induction of cell growth by insulin and insulin-like growth factor-I is associated with Jun expression in the otic vesicle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
36. [PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
37. [Differential effects of insulin-like growth factor-1 and atheroma-associated cytokines on cell proliferation and apoptosis in plaque smooth muscle cells of symptomatic and asymptomatic patients with carotid stenosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
38. [ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
39. [In vivo oocyte developmental competence is reduced in lean but not in obese superovulated dairy cows after intraovarian administration of IGF1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
40. [Insulin-like growth factor-I induces early osteoblast gene expression in human mesenchymal stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
41. [Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
42. [Involvement of Insulin-Like Growth Factor 1 Receptor Signaling in the Amyloid-β Peptide Oligomers-Induced p75 Neurotrophin Receptor Protein Expression in Mouse Hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
43. [Regulation of Insulin-Like Growth Factor-Binding Protein-5 by Insulin-Like Growth Factor I and Interleukin-1α in Ovine Articular Chondrocytes*](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
44. [One of two chondrocyte‐expressed isoforms of cartilage intermediate‐layer protein functions as an insulin‐like growth factor 1 antagonist](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
45. [Effects of insulin-like growth factors and insulin-like growth factor binding protein-2 on the in vitro proliferation of peripheral blood mononuclear cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
46. [The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
47. [Insulin-like Growth Factor-I Augments Erythropoietin-induced Proliferation through Enhanced Tyrosine Phosphorylation of STAT5](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05019&geneProductId=UniProtKB:P05019)
48. [Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226](http://www.ebi.ac.uk/QuickGO/annotations?protein=P05019&geneProductId=UniProtKB:P05019)
49. [Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)
50. [Insulin-like growth factor (IGF-I) induces myotube hypertrophy associated with an increase in anaerobic glycolysis in a clonal skeletal-muscle cell model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05019)