# Insulin induced gene 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21110728](https://www.wikidata.org/wiki/Q21110728)  
**Source**: https://4ort.xyz/entity/insulin-induced-gene-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O15503)
3. Q20641742
4. [Swiss-Prot](http://www.uniprot.org/uniprot/O15503.txt?version=132)
5. [Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503)
6. [Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503)
7. [Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503)
8. [Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503)
9. [Progesterone Receptor Membrane Component 1 Inhibits the Activity of Drug-Metabolizing Cytochromes P450 and Binds to Cytochrome P450 Reductase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503)
11. [Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15503)
12. [Cloning, Human Chromosomal Assignment, and Adipose and Hepatic Expression of the CL-6/INSIG1 Gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15503&geneProductId=UniProtKB:O15503)
13. Ensembl Release 99