# Insulin degrading enzyme

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28562356](https://www.wikidata.org/wiki/Q28562356)  
**Source**: https://4ort.xyz/entity/insulin-degrading-enzyme-q28562356


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P35559)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
5. [The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
6. [Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
7. [ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
8. [Insulin-degrading enzyme hydrolyzes ATP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
9. [Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
10. [Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
11. [Androgen- and estrogen-dependent regulation of insulin-degrading enzyme in subcellular fractions of rat prostate and uterus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
12. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
13. [Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
14. [Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
15. [ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35559&geneProductId=UniProtKB:P35559)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35559&geneProductId=UniProtKB:P35559)
17. [Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
18. [IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35559)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P35559&geneProductId=UniProtKB:P35559)
20. ensembl Release 104